Evidence map›Paper›PMID 26434507›Full record

ReviewJournal of molecular biology2015

Bacterial danger sensing.

Michele LeRoux, S Brook Peterson, Joseph D Mougous

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Antagonism by the type VI secretion system ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. A quorum-sensing molecule fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Polyamines and linear DNA mediate bacterial threat assessment of bacteriophage infection.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michele LeRouxDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
S Brook PetersonDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Joseph D MougousDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, Seattle, WA 98195, USA. Electronic address: mougous@uw.edu.

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Type VI secretion effectors and interbacterial competition in vivoR01AI080609 · NIAID · YALE UNIVERSITY · PI MOUGOUS, JOSEPH DAVID · 2009 to 2025
$6.7M
Elucidating the function of a novel antibacterial amidase in Ixodes scapularisR21AI114923 · NIAID · UNIVERSITY OF WASHINGTON · PI MOUGOUS, JOSEPH DAVID · 2015 to 2016
$439k
Linking apparatus dynamics to interbacterial intoxication by type VI secretionR21AI105268 · NIAID · UNIVERSITY OF WASHINGTON · PI MOUGOUS, JOSEPH DAVID, WIGGINS, PAUL A · 2013 to 2014
$412k
Howard Hughes Medical InstituteNIAID NIH HHS AI080609NIAID NIH HHS AI105268NIAID NIH HHS AI114923NIAID NIH HHS R01 AI080609NIAID NIH HHS R21 AI105268NIAID NIH HHS R21 AI114923NIGMS NIH HHS T32 GM007270NIGMS NIH HHS T32GM007270
6 · The paper itself

Abstract

Here we propose that bacteria detect and respond to threats posed by other bacteria via an innate immune-like process that we term danger sensing. We find support for this contention by reexamining existing literature from the perspective that intermicrobial antagonism, not opportunistic pathogenesis, is the major evolutionary force shaping the defensive behaviors of most bacteria. We conclude that many bacteria possess danger sensing pathways composed of a danger signal receptor and corresponding signal transduction mechanism that regulate pathways important for survival in the presence of the perceived competitor.

Indexed as

Bacterial Physiological PhenomenaAnti-Bacterial AgentsBacteriaBacterial ProteinsDNAGene Expression Regulation, BacterialSignal TransductionVibrio choleraeAnti-Bacterial AgentsBacterial ProteinsDNAPhoQ protein, BacteriacompetenceGac/Rsminterbacterialsubinhibitory antibioticstype VI secretion

Identifiers

PMID26434507
PMCPMC4658316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.