ArticleEuropean journal of nutrition2017
Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats.
Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer.Molecular biomedicine · 2025Review
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- Effects of Liquid Fructose Supplementation and Chronic Unpredictable Stress on Uterine Contractile Activity in Nonpregnant Rats.International journal of molecular sciences · 2024Article
- Article
- Oxidative Stress Linking Obesity and Cancer: Is Obesity a 'Radical Trigger' to Cancer?International journal of molecular sciences · 2023Review
- Effects of Fructose and Stress on Rat Renal Copper Metabolism and Antioxidant Enzymes Function.International journal of molecular sciences · 2022Article
- Total sugar intake is associated with higher prevalence of depressive symptoms in obese adults.Frontiers in public health · 2022Article
- Longitudinal associations of fruit juice intake in infancy with DXA-measured abdominal adiposity in mid-childhood and early adolescence.The American journal of clinical nutrition · 2021Article
- The metabolic effect of fructose on normal rats in a mild dose with glucose and saccharose as control.Food & nutrition research · 2021Article
- Fructose Induces Visceral Adipose Tissue Inflammation and Insulin Resistance Even Without Development of Obesity in Adult Female but Not in Male Rats.Frontiers in nutrition · 2021Article
- Fructose Consumption Affects Glucocorticoid Signaling in the Liver of Young Female Rats.Nutrients · 2020Article
- High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats.Mediators of inflammation · 2020Article
- KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.International journal of molecular sciences · 2019Article
- High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions.Nutrients · 2017Review
- Active-phase Plasma Alkaline Phosphatase Isozyme Activity Is a Sensitive Biomarker for Excessive Fructose Intake.In vivo (Athens, Greece)Article
- Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model.In vivo (Athens, Greece)Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe consumption of refined, fructose-enriched food continuously increases and has been linked to development of obesity, especially in young population. Low-grade inflammation and increased oxidative stress have been implicated in the pathogenesis of obesity-related disorders including type 2 diabetes. In this study, we examined alterations in inflammation and antioxidative defense system in the visceral adipose tissue (VAT) of fructose-fed young female rats, and related them to changes in adiposity and insulin sensitivity.
methodsWe examined the effects of 9-week fructose-enriched diet applied immediately after weaning on nuclear factor κB (NF-κB) intracellular distribution, and on the expression of pro-inflammatory cytokines (IL-1β and TNFα) and key antioxidative enzymes in the VAT of female rats. Insulin signaling in the VAT was evaluated at the level of insulin receptor substrate-1 (IRS-1) protein and its inhibitory phosphorylation on Ser
resultsFructose-fed rats had increased VAT mass along with increased NF-κB nuclear accumulation and elevated IL-1β, but not TNFα expression. The protein levels of antioxidative defense enzymes, mitochondrial manganese superoxide dismutase 2, and glutathione peroxidase, were reduced, while the protein content of IRS-1 and its inhibitory phosphorylation were not altered by fructose diet.
conclusionsThe results suggest that fructose overconsumption-related alterations in pro-inflammatory markers and antioxidative capacity in the VAT of young female rats can be implicated in the development of adiposity, but do not affect inhibitory phosphorylation of IRS-1.
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