Evidence map›Paper›PMID 26433736›Full record

ArticleEndocrine2016

Incidence of morphometric vertebral fractures in adult patients with growth hormone deficiency.

Gherardo Mazziotti, Mauro Doga, Stefano Frara, Filippo Maffezzoni, Teresa Porcelli, Luigi Cerri, Roberto Maroldi, Andrea Giustina

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856683 (PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04856683 unknown statusnot on this mapstarted 2020, after this paper: background citation

PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin

TypeobservationalSponsorUniversity of Roma La SapienzaRan2020 to 2024Enrolled1,100ConditionsFrailty
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  18. Acromegaly and Bone: An Update.Endocrinology and metabolism (Seoul, Korea) · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gherardo MazziottiEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Mauro DogaEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Stefano FraraEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Filippo MaffezzoniEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Teresa PorcelliEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Luigi CerriEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy.
Roberto MaroldiRadiology, University of Brescia, Brescia, Italy.
Andrea GiustinaEndocrinology, University of Brescia, Via Biseo, 17, 25123, Brescia, Italy. a.giustina@libero.it.
University of Brescia · ITAzienda Ospedaliera Carlo Poma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-sectional studies showed an elevated prevalence of clinical and morphometric vertebral fractures (VFs) in adult patients with growth hormone deficiency (GHD). However, no data are available on incidence and determinants of radiological VFs in this clinical setting. In this prospective study, we investigated the incidence and risk factors of radiological VFs in adults with GHD. Forty patients with GHD (28 males, 12 females; median age 44 years, range 19-82) were studied for incident VFs using quantitative morphometric approach on spine X-ray at baseline and after 6 years of follow-up. GHD patients were also studied for bone mineral density (BMD) measured by DXA at lumbar spine. After 6 years of follow-up, 12 patients (30 %) experienced incident VFs. Patients with incident VFs had more frequently untreated GHD and prevalent VFs at baseline, as compared to patients who did not experience incident VFs. Untreated GHD patients were significantly older as compared to treated GHD (50 years, range 19-82 vs. 36 years, range 19-75; p = 0.003), but the correlation between high risk of VFs and untreated GHD remained significant even after adjustment for the age of patients (odds ratio 6.8, CI 95 % 1.1-41.8; p = 0.037). In GHD patients experiencing incident VFs, lumbar spine BMD decreased significantly whereas it did not change in patients not developing VFs. This is the first prospective study confirming the hypothesis suggested by cross-sectional studies that untreated GHD may cause high risk of VFs in adult patients and that recombinant human GH treatment may effectively decrease such a risk.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsBone DensityBone Diseases, MetabolicCross-Sectional StudiesEndpoint DeterminationFemaleFollow-Up StudiesHuman Growth HormoneHumansHypopituitarismIncidenceLumbar VertebraeHuman Growth HormoneRecombinant ProteinsBone mineral densityGrowth hormone deficiencyIGF-IOsteoporosisVertebral fractures

Identifiers

PMID26433736
OpenAlexW1943837852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.