ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2016
Peroxiredoxin 6 from the Antarctic emerald rockcod: molecular characterization of its response to warming.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Tissue-specific oxidative responses and recovery following acute thermal stress in juvenile Amazonian fish Colossoma macropomum.Fish physiology and biochemistry · 2026Article
- Transcriptional response of transposable elements to thermal stress in the Antarctic fish Trematomus bernacchii.Scientific reports · 2026Article
- Delayed Reproduction, Injury, and Regeneration of Testes in Out-of-Season Breeding of Largemouth Bass (Antioxidants (Basel, Switzerland) · 2024Article
- Genomic organization and transcription of superoxide dismutase genes (Animal biotechnology · 2023Article
- Metallothionein Expression as a Physiological Response against Metal Toxicity in the Striped RockcodInternational journal of molecular sciences · 2022Article
- Temperature-Related Effects of Myocardial Protection Strategies in Swine Hearts after Prolonged Warm Ischemia.Antioxidants (Basel, Switzerland) · 2022Article
- Typical 2-Cys Peroxiredoxins as a Defense Mechanism against Metal-Induced Oxidative Stress in the Solitary AscidianAntioxidants (Basel, Switzerland) · 2021Article
- The Atlantic salmon's stress- and immune-related transcriptional responses to moderate hypoxia, an incremental temperature increase, and these challenges combined.G3 (Bethesda, Md.) · 2021Article
- The transcriptomic responses of Atlantic salmon (Salmo salar) to high temperature stress alone, and in combination with moderate hypoxia.BMC genomics · 2021Article
- Antarctic Fish as a Global Pollution Sensor: Metals Biomonitoring in a Twelve-Year Period.Frontiers in molecular biosciences · 2021Article
- Association between GPx-1 polymorphisms and personality traits in healthy Chinese-Han subjects.Brain and behavior · 2020Article
- Copper/Zinc Superoxide Dismutase from the Crocodile IcefishAntioxidants (Basel, Switzerland) · 2020Article
- Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population.Neuropsychiatric disease and treatment · 2020Article
- Molecular Characterization and Gene Expression of Glutathione Peroxidase 1 inEvolutionary bioinformatics online · 2019Article
- The phospholipase AJournal of lipid research · 2018Review
- Effects of Oxygen Availability on Oxidative Stress Biomarkers in the Mediterranean Mussel Mytilus galloprovincialis.Marine biotechnology (New York, N.Y.) · 2017Article
- Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.Archives of biochemistry and biophysics · 2017Review
- Cu,Zn Superoxide Dismutase Genes inFrontiers in immunology · 2017Article
- Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity.Free radical biology & medicine · 2016Article
- Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies.The Journal of biological chemistry · 2016Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we describe the purification and molecular characterization of two peroxiredoxins (Prdxs), referred to as Prdx6A and Prdx6B, from Trematomus bernacchii, a teleost widely distributed in many areas of Antarctica, that plays a pivotal role in the Antarctic food chain. The two putative amino acid sequences were compared with Prdx6 orthologs from other fish, highlighting a high percentage of identity and similarity with the respective variant, in particular for the residues that are essential for the characteristic peroxidase and phospholipase activities of these enzymes. Phylogenetic analyses suggest the appearance of the two prdx6 genes through a duplication event before the speciation that led to the differentiation of fish families and that the evolution of the two gene variants seems to proceed together with the evolution of fish orders and families. The temporal expression of Prdx6 mRNA in response to short-term thermal stress showed a general upregulation of prdx6b and inhibition of prdx6a, suggesting that the latter is the variant most affected by temperature increase. The variations of mRNA accumulation are more conspicuous in heart than the liver, probably related to behavioral changes of the specimens in response to elevated temperature. These data, together with the peculiar differences between the molecular structures of the two Prdx6s in T. bernacchii as well as in the tropical species Stegastes partitus, suggest an adaptation that allowed these poikilothermic aquatic vertebrates to colonize very different environments, characterized by different temperature ranges.
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