ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Antimicrobial peptides in anti-infective and immunomodulatory applications: Mechanisms, challenges, and emerging computational design.Zoological research · 2026Review
- Review
- Breaking the Cycle: Can Vitamin D Bridge the Gap Between Gut Microbiota and Immune Dynamics in Multiple Sclerosis?International journal of molecular sciences · 2025Review
- Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy population.Frontiers in endocrinology · 2025Article
- Associations of Serum Vitamin D With Dental Caries and Periodontitis: The HUNT Study.International dental journal · 2024Article
- Polymorphisms in vitamin D receptor genes and its relation with susceptibility to brucellosis: a case-control study.Molecular biology reports · 2023Article
- Osteoporosis and dermatoporosis: a review on the role of vitamin D.Frontiers in endocrinology · 2023Review
- Article
- Vitamin D3 promotes autophagy in THP-1 cells infected withExperimental and therapeutic medicine · 2022Article
- Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis.Frontiers in microbiology · 2022Review
- The Impact of Vitamin D on Skin Aging.International journal of molecular sciences · 2021Review
- Periodontal health and disease: The contribution of genetics.Periodontology 2000 · 2021Review
- Vitamin DOxidative medicine and cellular longevity · 2021Article
- Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- Vitamin D status and dental caries in healthy Swedish children.Nutrition journal · 2018Article
- The Decline in Vitamin Research Funding: A Missed Opportunity?Current developments in nutrition · 2017Article
- DNA methylation directly downregulates human cathelicidin antimicrobial peptide gene (CAMP) promoter activity.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.
resultsExperimental studies in various experimental systems show that 1,25D3 differentially regulates the production of pro-inflammatory cytokines and chemokines depending on cell type. Importantly, many reports show that 1,25D3 up-regulates expression of the human antimicrobial peptide hCAP-18/LL-37 gene. The hCAP-18/LL-37 gene seems indeed to be an important transcriptional target for 1,25D3. However, only limited evidence is presented showing that 1,25D3 consistently increases the amount of biologically active LL-37 peptide.
conclusionIn the present review, we discuss 1,25D3-induced down-regulation of cytokine/chemokine production and stimulation of hCAP-18/LL-37 gene expression which represent two very important pathways for 1,25D3-evoked regulation of the innate immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.