ArticleBMC public health2015
Outcomes of prevention of mother to child transmission of the human immunodeficiency virus-1 in rural Kenya--a cohort study.
Article in BMC public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Sexual and reproductive health of women living with HIV in Muslim-majority countries: a systematic mixed studies review.BMC international health and human rights · 2020Pooled it
- A systematic review and meta-analysis of vertical transmission route of HIV in Ethiopia.BMC infectious diseases · 2018Pooled it
- Pooled it
- Reproductive coercion experienced by women living with HIV - a global scoping review.Sexual and reproductive health matters · 2025Article
- Article
- Reduced mother-to-child transmission rates of HIV between 2017 and 2020 in Kenya. What changed?Journal of public health in Africa · 2024Article
- Prevention of mother-to-child transmission of HIV in Kermanshah, west of Iran from 2014 to 2021.BMC pediatrics · 2023Article
- Eliminating mother-to-child transmission of HIV in Tanzania calls for efforts to address factors associated with a low confirmatory test.PLOS global public health · 2023Article
- Client Experiences in a Mobile-Phone Counseling Intervention for Enhancing Access to Prevention of Mother To-Child Transmission (PMTCT) Services in Kenya.Frontiers in global women's health · 2022Article
- Article
- Achievements and Challenges in the Prevention of Mother-to-Child Transmission of HIV-A Retrospective Cohort Study from a Rural Hospital in Northern Tanzania.International journal of environmental research and public health · 2021Article
- Factors associated with typical enteropathogenicEpidemiology and infection · 2020Article
- Epidemiology of HIV Infection Among HIV-Exposed Infants, Nairobi County, Kenya, 2015.Infectious diseases · 2020Article
- Peripheral blood mononuclear cell transcriptomes reveal an over-representation of down-regulated genes associated with immunity in HIV-exposed uninfected infants.Scientific reports · 2019Article
- Rates and Predictors of HIV-Exposed Infants Lost to Follow-Up During Early Infant Diagnosis Services in Kenya.AIDS patient care and STDs · 2019Article
- Investigation of prevention of mother to child HIV transmission program from 2011 to 2017 in Suzhou, China.Scientific reports · 2018Article
- Men's hopes, fears and challenges in engagement in perinatal health and the prevention of mother-to-child transmission of HIV in rural Kenya.Culture, health & sexuality · 2018Article
- Article
- Predictors of post neonatal mortality in Western Kenya: a cohort study.The Pan African medical journal · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundSuccess in prevention of mother-to-child transmission (PMTCT) raises the prospect of eliminating pediatric HIV infection. To achieve global elimination, however, strategies are needed to strengthen PMTCT interventions. This study aimed to determine PMTCT outcomes and identify challenges facing its successful implementation in a rural setting in Kenya.
methodsA retrospective cohort design was used. Routine demographic and clinical data for infants and mothers enrolling for PMTCT care at a rural hospital in Kenya were analysed. Cox and logistic regression were used to determine factors associated with retention and vertical transmission respectively.
resultsBetween 2006 and 2012, 1338 infants were enrolled and followed up for PMTCT care with earlier age of enrollment and improved retention observed over time. Mother to child transmission of HIV declined from 19.4 % in 2006 to 8.9 % in 2012 (non-parametric test for trend p = 0.024). From 2009 to 2012, enrolling for care after 6 months of age, adjusted Odds Ratio [aOR]: 23.3 [95 % confidence interval (CI): 8.3-65.4], presence of malnutrition ([aOR]: 2.3 [95 % CI: 1.1-5.2]) and lack of maternal use of highly active antiretroviral therapy (HAART) (aOR: 6.5 [95 % CI: 1.4-29.4]) was associated with increased risk of HIV infection. Infant's older age at enrollment, malnutrition and maternal HAART status, were also associated with drop out from care. Infants who were not actively followed up were more likely to drop out from care (adjusted Hazard Ratio: 6.6 [95 % CI: 2.9-14.6]). DISCUSSION: We report a temporal increase in the proportion of infants enrolling for PMTCT care before 3 months of age, improved retention in PMTCT and a significant reduction in the proportion of infants enrolled who became HIV-infected, emphasizing the benefits of PMTCT.
conclusionA simple set of risk factors at enrollment can identify mother-infant pairs most at risk of infection or drop out for targeted intervention.
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