Evidence map›Paper›PMID 26433393›Full record

ArticleThe international journal of neuropsychopharmacology2015

Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia.

Alberto Corcoba, Pascal Steullet, João M N Duarte, Yohan Van de Looij, Aline Monin, Michel Cuenod, Rolf Gruetter, Kim Q Do

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  10. Hippocampal circuit dysfunction in psychosis.Translational psychiatry · 2022
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  20. White-matter commissures: a clinically focused anatomical review.Surgical and radiologic anatomy : SRA · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alberto CorcobaLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Pascal SteulletLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
João M N DuarteLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Yohan Van de LooijLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Aline MoninLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Michel CuenodLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Rolf GruetterLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter).
Kim Q DoLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (Mr Corcoba, and Drs Duarte, Van de Looij, and Gruetter); Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, CHUV, Lausanne, Switzerland (Mr Corcoba, Drs Steullet, Monin, Cuenod, and Do); Division of Child Growth & Development, University of Geneva, Geneva, Switzerland (Dr Van de Looij); Department of Radiology, University Hospital, Lausanne, Switzerland (Dr Gruetter); Department of Radiology, University Hospital, Geneva, Switzerland (Dr Gruetter). kim.do@chuv.ch.
University of Lausanne · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStructural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear. Oxidative stress and redox dysregulation have been proposed to play a role in the pathophysiology of several psychiatric conditions, but their anatomical and functional consequences are poorly understood. The aim of this study was to investigate white matter throughout the brain in a preclinical model of redox dysregulation.

methodsIn a mouse model with impaired glutathione synthesis (Gclm KO), a state-of-the-art multimodal magnetic resonance protocol at high field (14.1 T) was used to assess longitudinally the white matter structure, prefrontal neurochemical profile, and ventricular volume. Electrophysiological recordings in the abnormal white matter tracts identified by diffusion tensor imaging were performed to characterize the functional consequences of fractional anisotropy alterations.

resultsStructural alterations observed at peri-pubertal age and adulthood in Gclm KO mice were restricted to the anterior commissure and fornix-fimbria. Reduced fractional anisotropy in the anterior commissure (-7.5% ± 1.9, P<.01) and fornix-fimbria (-4.5% ± 1.3, P<.05) were accompanied by reduced conduction velocity in fast-conducting fibers of the posterior limb of the anterior commissure (-14.3% ± 5.1, P<.05) and slow-conducting fibers of the fornix-fimbria (-8.6% ± 2.6, P<.05). Ventricular enlargement was found at peri-puberty (+25% ± 8 P<.05) but not in adult Gclm KO mice.

conclusionsGlutathione deficit in Gclm KO mice affects ventricular size and the integrity of the fornix-fimbria and anterior commissure. This suggests that redox dysregulation could contribute during neurodevelopment to the impaired white matter and ventricle enlargement observed in schizophrenia and other psychiatric disorders.

Indexed as

AnimalsBrainDiffusion Tensor ImagingDisease Models, AnimalGlutamate-Cysteine LigaseGlutathioneMaleMice, KnockoutOrgan SizePyrrolesSchizophreniaTissue Culture TechniquesWhite MatterGCLM protein, mouseGlutamate-Cysteine LigaseGlutathionelongmide BPyrrolesanterior commissurefimbria-fornixglutathioneoxidative stressSchizophrenia

Identifiers

PMID26433393
PMCPMC4815475
OpenAlexW1945436779

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.