Evidence map›Paper›PMID 26433222›Full record

ArticleThe Journal of infectious diseases2016

Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia.

Kimberly M Fornace, Nor Afizah Nuin, Martha Betson, Matthew J Grigg, Timothy William, Nicholas M Anstey, Tsin W Yeo, Jonathan Cox, Lau Tiek Ying, Chris J Drakeley

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Improved limit of detection for zoonoticmedRxiv : the preprint server for health sciences · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Updating estimates ofmedRxiv : the preprint server for health sciences · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Increasing incidence ofFrontiers in public health · 2023
    Article
  18. Article
  19. Narrative Review of the Control and Prevention of Knowlesi Malaria.Tropical medicine and infectious disease · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kimberly M FornaceLondon School of Hygiene and Tropical Medicine.
Nor Afizah NuinBiotechnology Research Institute, Universiti Sabah Malaysia.
Martha BetsonRoyal Veterinary College, London, United Kingdom.
Matthew J GriggInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Menzies School of Health Research, Darwin, Australia.
Timothy WilliamInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Sabah Department of Health, Clinical Research Centre Jesselton Medical Centre, Kota Kinabalu, Malaysia.
Nicholas M AnsteyInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Menzies School of Health Research, Darwin, Australia.
Tsin W YeoInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Menzies School of Health Research, Darwin, Australia.
Jonathan CoxLondon School of Hygiene and Tropical Medicine.
Lau Tiek YingBiotechnology Research Institute, Universiti Sabah Malaysia.
Chris J DrakeleyLondon School of Hygiene and Tropical Medicine.

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G1100796
6 · The paper itself

Abstract

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

Indexed as

Carrier StatePlasmodium knowlesiAdolescentAdultFamily CharacteristicsFemaleHumansMalariaMalaysiaMaleMiddle AgedYoung Adultasymptomatic parasitemiamalariaPlasmodium knowlesisubmicroscopic infection

Identifiers

PMID26433222
PMCPMC4747612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.