ArticleDevelopmental biology2015
RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Hypothalamus Transcriptome Reveals Key lncRNAs and mRNAs Associated with Fecundity in Goats.Animals : an open access journal from MDPI · 2025Article
- Knock down analysis reveals critical phases for specific oskar noncoding RNA functions during Drosophila oogenesis.G3 (Bethesda, Md.) · 2021Article
- Different roles for the adjoining and structurally similar A-rich and poly(A) domains of oskar mRNA: Only the A-rich domain is required for oskar noncoding RNA function, which includes MTOC positioning.Developmental biology · 2021Article
- Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.PLoS genetics · 2021Article
- Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.PLoS genetics · 2020Article
- Comparative Transcriptomics Reveal Key Sheep (Ovis aries) Hypothalamus LncRNAs that Affect Reproduction.Animals : an open access journal from MDPI · 2019Article
- Long noncoding RNA and mRNA expression profiles following igf3 knockdown in common carp, Cyprinus carpio.Scientific data · 2019Article
- Review
- Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster.Developmental cell · 2016Article
- Community effects in regulation of translation.eLife · 2016Article
- Germ Line Mechanics--And Unfinished Business.Current topics in developmental biology · 2016Review
- Germ Plasm Biogenesis--An Oskar-Centric Perspective.Current topics in developmental biology · 2016Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila oskar (osk) mRNA is unusual in having both coding and noncoding functions. As an mRNA, osk encodes a protein which is deployed specifically at the posterior of the oocyte. This spatially-restricted deployment relies on a program of mRNA localization and both repression and activation of translation, all dependent on regulatory elements located primarily in the 3' untranslated region (UTR) of the mRNA. The 3' UTR also mediates the noncoding function of osk, which is essential for progression through oogenesis. Mutations which most strongly disrupt the noncoding function are positioned in a short region (the C region) near the 3' end of the mRNA, in close proximity to elements required for activation of translation. We show that Bicoid Stability Factor (BSF) binds specifically to the C region of the mRNA. Both knockdown of bsf and mutation of BSF binding sites in osk mRNA have the same consequences: Osk expression is largely eliminated late in oogenesis, with both mRNA localization and translation disrupted. Although the C region of the osk 3' UTR is required for the noncoding function, BSF binding does not appear to be essential for that function.
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