Evidence map›Paper›PMID 26432984›Full record

ArticleOsteoarthritis and cartilage2016

The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative.

C E Dubé, S-H Liu, J B Driban, T E McAlindon, C B Eaton, K L Lapane

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Impact of Nicotine Use on Osteoarthritis.Current rheumatology reviews · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Effect of smoking on the redox status of knee osteoarthritis: A preliminary study.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Understanding Atherosclerosis Through an Osteoarthritis Data Set.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Osteoarthritis year in review 2017: clinical.Osteoarthritis and cartilage · 2018
    Review
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

C E DubéDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: catherine.dube@umassmed.edu.
S-H LiuDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: ShaoHsien.Liu@umassmed.edu.
J B DribanDivision of Rheumatology, Tufts Medical Center, Boston, MA 02111, USA. Electronic address: Jeffrey.Driban@tufts.edu.
T E McAlindonDivision of Rheumatology, Tufts Medical Center, Boston, MA 02111, USA. Electronic address: tmcalindon@tuftsmedicalcenter.org.
C B EatonCenter for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA; Department of Family Medicine, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI 02912, USA; Department of Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI 02912, USA. Electronic address: CEaton@careNE.org.
K L LapaneDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: Kate.Lapane@umassmed.edu.
University of Massachusetts Chan Medical School · USTufts Medical Center · USBrown University · US

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
NEW PHARMACOLOGY ASPECTS RELATED TO CARBONIC ANHYDRASER01HL022258 · NHLBI · UNIVERSITY OF FLORIDA · PI MAREN, THOMAS H · 1985 to 1986
–
NHLBI NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS N01-AR-2-2258NIAMS NIH HHS N01-AR-2-2259NIAMS NIH HHS N01-AR-2-2260NIAMS NIH HHS N01-AR-2-2261NIAMS NIH HHS N01-AR-2-2262PHS HHS 268201000020C-1-0-1
6 · The paper itself

Abstract

objectiveTo estimate the extent that smoking history is associated with symptoms and disease progression among individuals with radiographically confirmed knee Osteoarthritis (OA).

methodBoth cross-sectional (baseline) and longitudinal studies employed data from the Osteoarthritis Initiative (OAI) (n = 2250 participants). Smoking history was assessed at baseline with 44% current or former smokers. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to measure knee pain, stiffness, and physical function. Disease progression was measured using joint space width (JSW). We used adjusted multivariable linear models to examine the relationship between smoking status and exposure in pack years (PY) with symptoms and JSW at baseline. Changes in symptoms and JSW over time were further assessed.

resultsIn cross-sectional analyses, compared to never-smokers high PY (≥15 PY) was associated with slightly greater pain (beta 0.36, 95% CI: 0.01-0.71) and stiffness (beta 0.20, 95% CI: 0.03-0.37); and low PY (<15 PY) was associated with better JSW (beta 0.15, 95% CI: 0.02-0.28). Current smoking was associated with greater pain (beta 0.59, 95% CI: 0.04-1.15) compared to never-smokers. These associations were not confirmed in the longitudinal study. Longitudinally, no associations were found between high or low PY or baseline smoking status with changes in symptoms (at 72 months) or JSW (at 48 months).

conclusionCross-sectional findings are likely due residual confounding. The more robust longitudinal analysis found no associations between smoking status and symptoms or JSW. Long-term smoking provides no benefits to knee OA patients while exposing them to other well-documented serious health risks.

Indexed as

AdolescentAdultAgedCross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedOsteoarthritis, KneePain MeasurementSeverity of Illness IndexSmokingSocioeconomic FactorsUnited StatesKnee osteoarthritisOsteoarthritis InitiativeSmoking

Identifiers

PMID26432984
PMCPMC4761327
OpenAlexW1819596178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.