Evidence map›Paper›PMID 26432947›Full record

ArticleMicrobes and infection2016

Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls.

Eleonora Passeri, Lorraine Jones-Brando, Claudia Bordón, Srona Sengupta, Ashley M Wilson, Amedeo Primerano, Judith L Rapoport, Koko Ishizuka, Shin-ichi Kano, Robert H Yolken and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbes and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Extracellular vesicles and circulating nucleic acids · 2026
    Article
  2. Use ofFrontiers in cellular and infection microbiology · 2023
    Review
  3. Depletion of Intracellular Glutamine Pools TriggersFrontiers in cellular and infection microbiology · 2021
    Article
  4. Article
  5. Review
  6. Unexpected encounter of the parasitic kind.World journal of stem cells · 2019
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eleonora PasseriDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Lorraine Jones-BrandoPediatrics, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Claudia BordónPediatrics, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Srona SenguptaDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Ashley M WilsonDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Amedeo PrimeranoDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Judith L RapoportNational Institute of Mental Health, Magnuson Clinical Center, Room 3N202, MSC 1600, Bethesda, MD 20814, USA.
Koko IshizukaDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Shin-ichi KanoDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA.
Robert H YolkenPediatrics, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA. Electronic address: rhyolken@gmail.com.
Akira SawaDepartments of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 North Wolfe St., Baltimore, MD 21287, USA. Electronic address: asawa1@jhmi.edu.
Johns Hopkins University · USNational Institute of Mental Health · US

Funding

Childhood Onset SchizophreniaZIAMH002581 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAPOPORT, JUDITH L. · 2009 to 2017
$25.5M
Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
Research Center for Molecular Pathogenesis of SchizophreniaP20MH084018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GALLAGHER, MICHAELA · 2008 to 2010
$3.3M
Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biologyR01MH069853 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2004 to 2012
$3.2M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 InteractioRC1MH088753 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, SAWA, AKIRA · 2009 to 2010
$933k
Role of glia and inflammation in altered synapse development in schizophreniaR00MH093458 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KANO, SHINICHI · 2014 to 2016
$737k
PICK1 knockout mice: role for D-serine in neonatal forebrainsR21MH085226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2010 to 2011
$369k
NIMH NIH HHS MH-069853NIMH NIH HHS MH-084018NIMH NIH HHS MH-085226NIMH NIH HHS MH-088753NIMH NIH HHS MH-092443NIMH NIH HHS MH-094268NIMH NIH HHS MH-105660NIMH NIH HHS P20 MH084018NIMH NIH HHS P50 MH094268NIMH NIH HHS R00 MH093458NIMH NIH HHS R01 MH069853NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH105660NIMH NIH HHS R21 MH085226NIMH NIH HHS RC1 MH088753
6 · The paper itself

Abstract

Toxoplasma gondii is a protozoan parasite capable of establishing persistent infection within the brain. Serological studies in humans have linked exposure to Toxoplasma to neuropsychiatric disorders. However, serological studies have not elucidated the related molecular mechanisms within neuronal cells. To address this question, we used human induced neuronal cells derived from peripheral fibroblasts of healthy individuals and patients with genetically-defined brain disorders (i.e. childhood-onset schizophrenia with disease-associated copy number variations). Parasite infection was characterized by differential detection of tachyzoites and tissue cysts in induced neuronal cells. This approach may aid study of molecular mechanisms underlying individual predisposition to Toxoplasma infection linked to neuropathology of brain disorders.

Indexed as

Host-Pathogen InteractionsBrain DiseasesCell Culture TechniquesCells, CulturedHumansNeuronsParasitologyToxoplasmaBrain disordersCystsInduced neuronal cellsSchizophreniaTachyzoitesToxoplasma gondii

Identifiers

PMID26432947
PMCPMC4758902
OpenAlexW1814175552

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.