ArticleJournal of the American Society of Nephrology : JASN2016
The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- DNA Damage and Bisphenol Levels in Chronic Kidney Disease Patients Undergoing Hemodialysis.Journal of xenobiotics · 2025Article
- Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review.Environmental health perspectives · 2024Article
- Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases.Journal of xenobiotics · 2023Review
- Bisphenol A and Bisphenol S in Hemodialyzers.Toxins · 2023Article
- Renoprotective effect of N-acetylcystein and vitamin E in bisphenol A-induced rat nephrotoxicity; Modulators of Nrf2/ NF-κB and ROS signaling pathway.Acta bio-medica : Atenei Parmensis · 2022Article
- Associations between pediatric intensive care procedures and urinary free-BPA levels.Environmental science and pollution research international · 2022Article
- Strategies to Protect Dialysis Patients against Bisphenol A.Biomolecules · 2021Review
- Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice.International journal of molecular sciences · 2021Article
- Toxin Removal and Inflammatory State Modulation during Online Hemodiafiltration Using Two Different Dialyzers (TRIAD2 Study).Methods and protocols · 2021Article
- Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A.Clinical kidney journal · 2021Article
- Bisphenol A impaired cell adhesion by altering the expression of adhesion and cytoskeleton proteins on human podocytes.Scientific reports · 2020Article
- Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure.Environmental health perspectives · 2019Article
- Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration.Biomolecules · 2019Article
- The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats.Environmental science and pollution research international · 2019Article
- Does plastic chemical exposure contribute to sudden death of patients on dialysis?Heart rhythm · 2019Review
- Current approaches to middle molecule removal: room for innovation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Review
- Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies.Oxidative medicine and cellular longevity · 2018Article
- Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration.PloS one · 2018Article
- The incidence of urinary tract cancers is related to preserved diuresis: a single-center report.International urology and nephrology · 2017Article
- Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease.Nutrients · 2017Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA), a component of some dialysis membranes, accumulates in CKD. Observational studies have linked BPA exposure to kidney and cardiovascular injury in humans, and animal studies have described a causative link. Normal kidneys rapidly excrete BPA, but insufficient excretion may sensitize patients with CKD to adverse the effects of BPA. Using a crossover design, we studied the effect of dialysis with BPA-containing polysulfone or BPA-free polynephron dialyzers on BPA levels in 69 prevalent patients on hemodialysis: 28 patients started on polysulfone dialyzers and were switched to polynephron dialyzers; 41 patients started on polynephron dialyzers and were switched to polysulfone dialyzers. Results were grouped for analysis. Mean BPA levels increased after one hemodialysis session with polysulfone dialyzers but not with polynephron dialyzers. Chronic (3-month) use of polysulfone dialyzers did not significantly increase predialysis serum BPA levels, although a trend toward increase was detected (from 48.8±6.8 to 69.1±10.1 ng/ml). Chronic use of polynephron dialyzers reduced predialysis serum BPA (from 70.6±8.4 to 47.1±7.5 ng/ml, P<0.05). Intracellular BPA in PBMCs increased after chronic hemodialysis with polysulfone dialyzers (from 0.039±0.002 to 0.043±0.001 ng/10(6) cells, P<0.01), but decreased with polynephron dialyzers (from 0.045±0.001 to 0.036±0.001 ng/10(6) cells, P<0.01). Furthermore, chronic hemodialysis with polysulfone dialyzers increased oxidative stress in PBMCs and inflammatory marker concentrations in circulation. In vitro, polysulfone membranes released significantly more BPA into the culture medium and induced more cytokine production in cultured PBMCs than did polynephron membranes. In conclusion, dialyzer BPA content may contribute to BPA burden in patients on hemodialysis.
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Registered trials
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