ArticleProceedings of the National Academy of Sciences of the United States of America2015
Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 71 citations in OpenAlex.
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination.Experimental & molecular medicine · 2026Article
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- The cerebellum converts input data into a hyper low-resolution granule cell code with spatial dimensions: a hypothesis.Royal Society open science · 2025Article
- GlyT2-Positive Interneurons Regulate Timing and Variability of Information Transfer in a Cerebellar-Behavioral Loop.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis.Cerebellum (London, England) · 2024Article
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- Packet information encoding in a cerebellum-like circuit.PloS one · 2024Article
- Patch-seq: Advances and Biological Applications.Cellular and molecular neurobiology · 2023Review
- Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.Neuron · 2023Article
- A cranial implant for stabilizing whole-cell patch-clamp recordings in behaving rodents.Journal of neuroscience methods · 2023Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties.Nature neuroscience · 2022Article
- How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.Frontiers in cellular neuroscience · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Classical feed-forward inhibition involves an excitation-inhibition sequence that enhances the temporal precision of neuronal responses by narrowing the window for synaptic integration. In the input layer of the cerebellum, feed-forward inhibition is thought to preserve the temporal fidelity of granule cell spikes during mossy fiber stimulation. Although this classical feed-forward inhibitory circuit has been demonstrated in vitro, the extent to which inhibition shapes granule cell sensory responses in vivo remains unresolved. Here we combined whole-cell patch-clamp recordings in vivo and dynamic clamp recordings in vitro to directly assess the impact of Golgi cell inhibition on sensory information transmission in the granule cell layer of the cerebellum. We show that the majority of granule cells in Crus II of the cerebrocerebellum receive sensory-evoked phasic and spillover inhibition prior to mossy fiber excitation. This preceding inhibition reduces granule cell excitability and sensory-evoked spike precision, but enhances sensory response reproducibility across the granule cell population. Our findings suggest that neighboring granule cells and Golgi cells can receive segregated and functionally distinct mossy fiber inputs, enabling Golgi cells to regulate the size and reproducibility of sensory responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.