Evidence map›Paper›PMID 26432871›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2015

ncRNA-regulated immune response and its role in inflammatory lung diseases.

Na Xie, Gang Liu

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  11. The Emerging Role of Circ-SHPRH in Cancer.OncoTargets and therapy · 2021
    Review
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  19. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Na XieDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Gang LiuDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama gliu@uab.edu.
University of Alabama at Birmingham · US

Funding

Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseP01HL114470 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2013 to 2022
$17.8M
Urokinase, Neutrophil Activation and Acute Lung Injury.R01HL076206 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LIU, GANG · 2005 to 2013
$2.8M
miR-21 and lung fibrosisR01HL105473 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, GANG · 2011 to 2015
$1.8M
NHLBI NIH HHS HL-076206NHLBI NIH HHS HL-105473NHLBI NIH HHS HL-114470NHLBI NIH HHS P01 HL114470NHLBI NIH HHS R01 HL076206NHLBI NIH HHS R01 HL105473
6 · The paper itself

Abstract

Despite the greatly expanded knowledge on the regulation of immune response by protein molecules, there is increasing understanding that noncoding RNAs (ncRNAs) are also an integral component of this regulatory network. Abnormal immune response serves a central role in the initiation, progression, and exacerbation of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and acute respiratory distress syndrome/acute lung injury. Dysregulation of ncRNAs has been linked to various immunopathologies. In this review, we highlighted the role of ncRNAs in the regulation of innate and adaptive immunity and summarized recent findings that ncRNAs participate in the pathogenesis of inflammatory lung diseases via their regulation of pulmonary immunity. We also discussed therapeutic potentials for targeting ncRNAs to treat these lung disorders.

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsAsthmaCystic FibrosisHumansLungPulmonary Disease, Chronic ObstructiveRespiratory Distress SyndromeRNA InterferenceRNA, UntranslatedRNA, Untranslatedacute respiratory distress syndromeasthmachronic obstructive pulmonary diseasecystic fibrosisimmunitynoncoding ribonucleic acid

Identifiers

PMID26432871
PMCPMC4652151
OpenAlexW2197954787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.