ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 49 citations in OpenAlex.
- Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue.Life metabolism · 2026Article
- Connexin-43-Mediated Gap Junction Coupling Between Adipocytes Regulates Norepinephrine-Induced CaCells · 2026Article
- Role of solute carrier transporters in the biodistribution and toxicity of chemotherapeutic drugs.Pharmacological reviews · 2026Review
- Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure.Clinical science (London, England : 1979) · 2025Article
- Sympathetic nerves are sparsely distributed in rat mesenteric perivascular adipose tissue.Frontiers in physiology · 2025Article
- Innervation of adipocytes is limited in mouse perivascular adipose tissue.American journal of physiology. Heart and circulatory physiology · 2024Article
- Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Review
- Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus.Brain research · 2023Article
- Adipokines: Deciphering the cardiovascular signature of adipose tissue.Biochemical pharmacology · 2022Review
- Adipocyte-derived relaxing factor-a fat load to be learnt.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Reciprocal signaling between adipose tissue depots and the central nervous system.Frontiers in cell and developmental biology · 2022Review
- Prenatal Exposure to Methamphetamine Causes Vascular Dysfunction in Adult Male Rat Offspring.Frontiers in cardiovascular medicine · 2022Article
- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions.Reviews of physiology, biochemistry and pharmacology · 2022Article
- Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens.The European journal of neuroscience · 2020Article
- Mechanisms underlying suppression of noradrenaline-induced contraction by prolonged treatment with advanced glycation end-products in organ-cultured rat carotid artery.Pflugers Archiv : European journal of physiology · 2020Article
- Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat.Autonomic neuroscience : basic & clinical · 2019Article
- Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer.International journal of cancer · 2019Article
- Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue.Cardiovascular drugs and therapy · 2019Review
- Perivascular Adipocytes Store Norepinephrine by Vesicular Transport.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Perivascular adipose tissue (PVAT) reduces vasoconstriction to norepinephrine (NE). A mechanism by which PVAT could function to reduce vascular contraction is by decreasing the amount of NE to which the vessel is exposed. PVATs from male Sprague-Dawley rats were used to test the hypothesis that PVAT has a NE uptake mechanism. NE was detected by HPLC in mesenteric PVAT and isolated adipocytes. Uptake of NE (10 μM) in mesenteric PVAT was reduced by the NE transporter (NET) inhibitor nisoxetine (1 μM, 73.68 ± 7.62%, all values reported as percentages of vehicle), the 5-hydroxytryptamine transporter (SERT) inhibitor citalopram (100 nM) with the organic cation transporter 3 (OCT3) inhibitor corticosterone (100 μM, 56.18 ± 5.21%), and the NET inhibitor desipramine (10 μM) with corticosterone (100 μM, 61.18 ± 6.82%). Aortic PVAT NE uptake was reduced by corticosterone (100 μM, 53.01 ± 10.96%). Confocal imaging of mesenteric PVAT stained with 4-[4-(dimethylamino)-styrl]-N-methylpyridinium iodide (ASP(+)), a fluorescent substrate of cationic transporters, detected ASP(+) uptake into adipocytes. ASP(+) (2 μM) uptake was reduced by citalopram (100 nM, 66.68 ± 6.43%), corticosterone (100 μM, 43.49 ± 10.17%), nisoxetine (100 nM, 84.12 ± 4.24%), citalopram with corticosterone (100 nM and 100 μM, respectively, 35.75 ± 4.21%), and desipramine with corticosterone (10 and 100 μM, respectively, 50.47 ± 5.78%). NET protein was not detected in mesenteric PVAT adipocytes. Expression of Slc22a3 (OCT3 gene) mRNA and protein in PVAT adipocytes was detected by RT-PCR and immunocytochemistry, respectively. These end points support the presence of a transporter-mediated NE uptake system within PVAT with a potential mediator being OCT3.
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