Evidence map›Paper›PMID 26432837›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2015

Cardiovascular response to thermoregulatory challenges.

Cuiqing Liu, Zubin Yavar, Qinghua Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cuiqing LiuBasic Medical College, Zhejiang Chinese Medical University, Hangzhou, China; and.
Zubin YavarDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio.
Qinghua SunDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio sun.224@osu.edu.

Funding

Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?R01ES018900 · NIEHS · OHIO STATE UNIVERSITY · PI SUN, QINGHUA · 2011 to 2015
$1.7M
Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?R56ES018900 · NIEHS · OHIO STATE UNIVERSITY · PI SUN, QINGHUA · 2010 to 2010
$153k
NIEHS NIH HHS ES018900NIEHS NIH HHS R01 ES018900
6 · The paper itself

Abstract

A growing number of extreme climate events are occurring in the setting of ongoing climate change, with an increase in both the intensity and frequency. It has been shown that ambient temperature challenges have a direct and highly varied impact on cardiovascular health. With a rapidly growing amount of literature on this issue, we aim to review the recent publications regarding the impact of cold and heat on human populations with regard to cardiovascular disease (CVD) mortality/morbidity while also examining lag effects, vulnerable subgroups, and relevant mechanisms. Although the relative risk of morbidity/mortality associated with extreme temperature varied greatly across different studies, both cold and hot temperatures were associated with a positive mean excess of cardiovascular deaths or hospital admissions. Cause-specific study of CVD morbidity/mortality indicated that the sensitivity to temperature was disease-specific, with different patterns for acute and chronic ischemic heart disease. Vulnerability to temperature-related mortality was associated with some characteristics of the populations, including sex, age, location, socioeconomic condition, and comorbidities such as cardiac diseases, kidney diseases, diabetes, and hypertension. Temperature-induced damage is thought to be related to enhanced sympathetic reactivity followed by activation of the sympathetic nervous system, renin-angiotensin system, as well as dehydration and a systemic inflammatory response. Future research should focus on multidisciplinary adaptation strategies that incorporate epidemiology, climatology, indoor/building environments, energy usage, labor legislative perfection, and human thermal comfort models. Studies on the underlying mechanism by which temperature challenge induces pathophysiological response and CVD await profound and lasting investigation.

Indexed as

AcclimatizationBody Temperature RegulationClimate ChangeCold TemperatureHot TemperatureSeasonsAnimalsCardiovascular DiseasesCardiovascular SystemFeverHumansHypothermiaRisk AssessmentRisk Factorscardiovascularcoldheatmechanismvulnerability

Identifiers

PMID26432837
PMCPMC4698386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.