ArticleParasitology international2016
Heterogeneous infectiousness in guinea pigs experimentally infected with Trypanosoma cruzi.
Article in Parasitology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Seasonal variations of Triatoma dimidiata demography and Trypanosoma cruzi transmission within its multi-host community in the Yucatan Peninsula, Mexico: Insights from an integrative SIR eco-epidemiological modelling.PLoS neglected tropical diseases · 2026Article
- Common Bed Bugs: Non-Viable Hosts forCells · 2024Article
- Modeling the impact of xenointoxication in dogs to halt Trypanosoma cruzi transmission.PLoS computational biology · 2023Article
- Modeling the impact of xenointoxication in dogs to haltmedRxiv : the preprint server for health sciences · 2023Article
- Elucidating the Mechanism ofTropical medicine and infectious disease · 2020Article
- Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru.PLoS neglected tropical diseases · 2020Article
- Sexual reproduction in a natural Trypanosoma cruzi population.PLoS neglected tropical diseases · 2019Article
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- Quantitative and histological assessment of maternal-fetal transmission of Trypanosoma cruzi in guinea pigs: An experimental model of congenital Chagas disease.PLoS neglected tropical diseases · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Guinea pigs are important reservoirs of Trypanosoma cruzi, the causative parasite of Chagas disease, and in the Southern Cone of South America, transmission is mediated mainly by the vector Triatoma infestans. Interestingly, colonies of Triatoma infestans captured from guinea pig corrals sporadically have infection prevalence rates above 80%. Such high values are not consistent with the relatively short 7-8 week parasitemic period that has been reported for guinea pigs in the literature. We experimentally measured the infectious periods of a group of T. cruzi-infected guinea pigs by performing xenodiagnosis and direct microscopy each week for one year. Another group of infected guinea pigs received only direct microscopy to control for the effect that inoculation by triatomine saliva may have on parasitemia in the host. We observed infectious periods longer than those previously reported in a number of guinea pigs from both the xenodiagnosis and control groups. While some guinea pigs were infectious for a short time, other "super-shedders" were parasitemic up to 22 weeks after infection, and/or positive by xenodiagnosis for a year after infection. This heterogeneity in infectiousness has strong implications for T. cruzi transmission dynamics and control, as super-shedder guinea pigs may play a disproportionate role in pathogen spread.
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Registered trials
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