Trial reportJournal of general internal medicine2016
Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk.
Trial report in Journal of general internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Community prevalence and dyad disease pattern of multimorbidity in China and India: a systematic review.BMJ global health · 2022Pooled it
- Emotional distress, anxiety, and depression in South Asians with long-term conditions: a qualitative systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Pooled it
- Multimorbidity of non-communicable diseases in low-income and middle-income countries: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice.The Cochrane database of systematic reviews · 2021Pooled it
- A systematic review of care management interventions targeting multimorbidity and high care utilization.BMC health services research · 2018Pooled it
- AIDEBMC geriatrics · 2026Trial
- Effect of Metabolic Syndrome on Late-Life Depression: Associations with Disease Severity and Treatment Resistance.Journal of the American Geriatrics Society · 2017Trial
- Associations Between Major Depressive Disorder, Multimorbidity Burden, and Inflammatory Biomarkers (NLR, PLR, MLR, SII, and MHR) in a Primary Care Population.Journal of clinical medicine · 2026Article
- Late-life depression and risk of all-cause and cause-specific mortality in an Asian population: the Singapore Chinese Health Study.BMJ public health · 2026Article
- Article
- Physical multimorbidity and dynapenic abdominal obesity among older adults from low- and middle-income countries.Communications medicine · 2025Article
- Age-specific Multimorbidity Patterns and Burden on All-Cause Mortality and Public Direct Medical Expenditure: A Retrospective Cohort Study.Journal of epidemiology and global health · 2024Observational
- Burnout Education: Are We Playing with Fire?American journal of respiratory and critical care medicine · 2024Article
- Association of dietary intake of live microbes with bowel health and depression in US adults: a cross-sectional study of NHANES 2005-2010.Environmental health and preventive medicine · 2024Article
- Eating disorders and physical multimorbidity in the English general population.Eating and weight disorders : EWD · 2023Article
- A protocol for a wait list control trial of an intervention to improve pain and depressive symptoms among middle-aged and older African American women.Contemporary clinical trials · 2023Article
- Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing.Aging clinical and experimental research · 2023Article
- Depressive symptoms and mortality-findings from Helsinki birth cohort study.Acta psychiatrica Scandinavica · 2023Article
- Article
- Depression complexity prevalence and outcomes among veterans affairs patients in integrated primary care.Families, systems & health : the journal of collaborative family healthcare · 2022Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
backgroundTwo-thirds of older adults have two or more medical conditions that often take precedence over depression in primary care.
objectiveWe evaluated whether evidence-based depression care management would improve the long-term mortality risk among older adults with increasing levels of medical comorbidity.
designLongitudinal analyses of the practice-randomized Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT). Twenty primary care practices randomized to intervention or usual care. PATIENTS: The sample included 1204 older primary care patients completing the Charlson Comorbidity Index (CCI) and other interview questions at baseline.
interventionFor 2 years, a depression care manager worked with primary care physicians to provide algorithm-based care for depression, offering psychotherapy, increasing the antidepressant dose if indicated, and monitoring symptoms, medication adverse effects, and treatment adherence. MAIN MEASURES: Depression status based on clinical interview, CCI to evaluate medical comorbidity, and vital status at 8 years (National Death Index). KEY
resultsIn the usual care condition, patients with the highest levels of medical comorbidity and depression were at increased risk of mortality over the course of the follow-up compared to depressed patients with minimal medical comorbidity [hazard ratio 3.02 (95% CI, 1.32 to 8.72)]. In contrast, in intervention practices, patients with the highest level of medical comorbidity and depression compared to depressed patients with minimal medical comorbidity were not at significantly increased risk [hazard ratio 1.73 (95% CI, 0.86 to 3.96)]. Nondepressed patients in intervention and usual care practices had similar mortality risk.
conclusionsDepression management mitigated the combined effect of multimorbidity and depression on mortality. Depression management should be integral to optimal patient care, not a secondary focus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.