ArticleThe Journal of biological chemistry2015
The Phytosiderophore Efflux Transporter TOM2 Is Involved in Metal Transport in Rice.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Meta-QTL s and haplotypes for efficient zinc biofortification of rice.The plant genome · 2023Pooled it
- Developmental stage-specific disruption of iron allocation by a ZmYSL2 mutation in maize.Planta · 2026Article
- Identification of the Nicotianamine synthase (NAS) gene family in wheat (Triticum aestivum L.) and the role of its member TaNAS4-A in Zn and Fe transport.Functional & integrative genomics · 2025Article
- Single-cell transcriptional decoding of iron deficiency responses in maize root tips.Plant cell reports · 2025Article
- Microrchidia OsMORC6 Positively Regulates Cadmium Tolerance and Uptake by Mediating DNA Methylation in Rice.Rice (New York, N.Y.) · 2025Article
- Brassinosteroids in Micronutrient Homeostasis: Mechanisms and Implications for Plant Nutrition and Stress Resilience.Plants (Basel, Switzerland) · 2025Review
- A Mitochondrial Localized Chaperone Regulator OsBAG6 Functions in Saline-Alkaline Stress Tolerance in Rice.Rice (New York, N.Y.) · 2024Article
- OsUGE2 Regulates Plant Growth through Affecting ROS Homeostasis and Iron Level in Rice.Rice (New York, N.Y.) · 2024Article
- OsMDH12: A Peroxisomal Malate Dehydrogenase Regulating Tiller Number and Salt Tolerance in Rice.Plants (Basel, Switzerland) · 2023Article
- Iron Nutrition in Plants: Towards a New Paradigm?Plants (Basel, Switzerland) · 2023Review
- Multilayered regulation of iron homeostasis in Arabidopsis.Frontiers in plant science · 2023Review
- Research progress on iron absorption, transport, and molecular regulation strategy in plants.Frontiers in plant science · 2023Review
- Functional verification and screening of protein interacting with the slPHB3.Plant signaling & behavior · 2022Article
- Identification of Zinc Efficiency-Associated Loci (International journal of molecular sciences · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- Genome-wide analysis of the NAAT, DMAS, TOM, and ENA gene families in maize suggests their roles in mediating iron homeostasis.BMC plant biology · 2022Article
- Strategies and Bottlenecks in Hexaploid Wheat to Mobilize Soil Iron to Grains.Frontiers in plant science · 2022Review
- Superior Haplotypes for Early Root Vigor Traits in Rice Under Dry Direct Seeded Low Nitrogen Condition Through Genome Wide Association Mapping.Frontiers in plant science · 2022Article
- Genomic approaches for improving grain zinc and iron content in wheat.Frontiers in genetics · 2022Review
- Diverse Functions of Plant Zinc-Induced Facilitator-like Transporter for Their Emerging Roles in Crop Trait Enhancement.Plants (Basel, Switzerland) · 2021Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential metal element for all living organisms. Graminaceous plants produce and secrete mugineic acid family phytosiderophores from their roots to acquire iron in the soil. Phytosiderophores chelate and solubilize insoluble iron hydroxide in the soil. Subsequently, plants take up iron-phytosiderophore complexes through specific transporters on the root cell membrane. Phytosiderophores are also thought to be important for the internal transport of various transition metals, including iron. In this study, we analyzed TOM2 and TOM3, rice homologs of transporter of mugineic acid family phytosiderophores 1 (TOM1), a crucial efflux transporter directly involved in phytosiderophore secretion into the soil. Transgenic rice analysis using promoter-β-glucuronidase revealed that TOM2 was expressed in tissues involved in metal translocation, whereas TOM3 was expressed only in restricted parts of the plant. Strong TOM2 expression was observed in developing tissues during seed maturation and germination, whereas TOM3 expression was weak during seed maturation. Transgenic rice in which TOM2 expression was repressed by RNA interference showed growth defects compared with non-transformants and TOM3-repressed rice. Xenopus laevis oocytes expressing TOM2 released (14)C-labeled deoxymugineic acid, the initial phytosiderophore compound in the biosynthetic pathway in rice. In onion epidermal and rice root cells, the TOM2-GFP fusion protein localized to the cell membrane, indicating that the TOM2 protein is a transporter for phytosiderophore efflux to the cell exterior. Our results indicate that TOM2 is involved in the internal transport of deoxymugineic acid, which is required for normal plant growth.
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