ArticleVirchows Archiv : an international journal of pathology2015
Secretory IgA from submucosal glands does not compensate for its airway surface deficiency in chronic obstructive pulmonary disease.
Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Crosstalk between the microbiome and the mucosal immunoglobulin A system in the lung, in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Small airway disease as a key factor in COPD: new perspectives and insights.Frontiers in medicine · 2025Review
- Review
- Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel (Camelus bactrianus) lungs.PloS one · 2022Article
- Yifei Sanjie Formula Treats Chronic Obstructive Pulmonary Disease by Remodeling Pulmonary Microbiota.Frontiers in medicine · 2022Article
- The relationship between airway immunoglobulin activity and eosinophils in COPD.Journal of cellular and molecular medicine · 2021Article
- Stem cells part of the innate and adaptive immune systems as a therapeutic for Covid-19.Communicative & integrative biology · 2021Review
- Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates.Respiratory research · 2019Article
- The pathology of small airways disease in COPD: historical aspects and future directions.Respiratory research · 2019Review
- Carbocisteine inhibits the expression of Muc5b in COPD mouse model.Drug design, development and therapy · 2019Article
- Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling.American journal of respiratory and critical care medicine · 2017Article
- A Hairline Crack in the Levee: Focal Secretory IgA Deficiency as a First Step toward Emphysema.American journal of respiratory and critical care medicine · 2017Article
- Lung Dendritic Cells: Shaping Immune Responses throughout Chronic Obstructive Pulmonary Disease Progression.American journal of respiratory cell and molecular biology · 2017Review
- Specific IgA againstInternational journal of chronic obstructive pulmonary disease · 2017Article
- Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.Nature communications · 2016Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Secretory immunoglobulin A (SIgA) reaches the airway lumen by local transcytosis across airway epithelial cells or with tracheobronchial submucosal gland secretions. In chronic obstructive pulmonary disease (COPD), deficiency of SIgA on the airway surface has been reported. However, reduction of SIgA levels in sputum and bronchoalveolar lavage (BAL) fluid has not been consistently observed. To explain this discrepancy, we analyzed BAL fluid and lung tissue from patients with COPD and control subjects. Immunohistochemical analysis of large and small airways of COPD patients showed that MUC5AC is the predominant mucin expressed by airway epithelial cells, whereas MUC5B is expressed in submucosal glands of large airways. Dual immunostaining with anti-IgA and anti-MUC5B antibodies showed reduction of IgA on the airway surface as well as accumulation of IgA within MUC5B-positive luminal mucus plugs, suggesting that luminal SIgA originates from submucosal glands in COPD patients. We found that the concentration of SIgA in BAL is inversely correlated with forced expiratory volume in 1 s (FEV
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