Evidence map›Paper›PMID 26432413›Full record

ReviewCurrent opinion in structural biology2015

Crystallographic phasing from weak anomalous signals.

Qun Liu, Wayne A Hendrickson

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. X-Ray Crystallography for Macromolecular Complexes.Advances in experimental medicine and biology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. xia2.multiplex: a multi-crystal data-analysis pipeline.Acta crystallographica. Section D, Structural biology · 2022
    Article
  8. Current research in structural biology · 2021
    Article
  9. Article
  10. Article
  11. Transforming X-ray detection with hybrid photon counting detectors.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019
    Article
  12. Article
  13. Making routine native SAD a reality: lessons from beamline X06DA at the Swiss Light Source.Acta crystallographica. Section D, Structural biology · 2019
    Article
  14. Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ.Journal of the American Chemical Society · 2018
    Article
  15. KAMO: towards automated data processing for microcrystals.Acta crystallographica. Section D, Structural biology · 2018
    Article
  16. SLS-2 - the upgrade of the Swiss Light Source.Journal of synchrotron radiation · 2018
    Article
  17. Review
  18. Article
  19. Article
  20. The crystal structure of full-length Sizzled fromThe Journal of biological chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qun LiuNew York Consortium on Membrane Protein Structure, New York Structural Biology Center, New York, NY 10027, USA. Electronic address: qunliu@bnl.gov.
Wayne A HendricksonNew York Consortium on Membrane Protein Structure, New York Structural Biology Center, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: wayne@xtl.cumc.columbia.edu.

Funding

Structural Genomics on Membrane ProteinsU54GM095315 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ROST, BURKHARD · 2010 to 2014
$15.2M
Proposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6M
Intramural NIH HHSNIGMS NIH HHS GM095315NIGMS NIH HHS GM107462NIGMS NIH HHS R01 GM107462NIGMS NIH HHS U54 GM095315
6 · The paper itself

Abstract

The exploitation of anomalous signals for biological structural solution is maturing. Single-wavelength anomalous diffraction (SAD) is dominant in de novo structure analysis. Nevertheless, for challenging structures where the resolution is low (dmin≥3.5Å) or where only lighter atoms (Z≤20) are present, as for native macromolecules, solved SAD structures are still scarce. With the recent rapid development in crystal handling, beamline instrumentation, optimization of data collection strategies, use of multiple crystals and structure determination technologies, the weak anomalous diffraction signals are now robustly measured and should be used for routine SAD structure determination. The review covers these recent advances on weak anomalous signals measurement, analysis and utilization.

Indexed as

CrystallizationCrystallography, X-RayModels, MolecularMolecular ConformationX-Ray Diffraction

Identifiers

PMID26432413
PMCPMC4684729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.