ReviewPharmacology, biochemistry, and behavior2015
Cocaine choice procedures in animals, humans, and treatment-seekers: Can we bridge the divide?
Review in Pharmacology, biochemistry, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Ultra-brief breath counting (mindfulness) training promotes recovery from stress-induced alcohol-seeking in student drinkers.Addictive behaviors · 2020Trial
- Influence of phendimetrazine maintenance on the reinforcing, subjective, performance, and physiological effects of intranasal cocaine.Psychopharmacology · 2019Trial
- Development of a translational model to screen medications for cocaine use disorder II: Choice between intravenous cocaine and money in humans.Drug and alcohol dependence · 2016Trial
- Dissociation of decision-making from escalated drug intake within a long-access model.Behavioural brain research · 2026Article
- Neurobehavioral differences in value-based decision making between people with cocaine use disorder and controls.Experimental and clinical psychopharmacology · 2026Article
- PGx-BasedCurrent neuropharmacology · 2026Article
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
- Tobacco Images Choice and its Association With Craving and Dependence in People Who Smoke Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Human laboratory models of reward in substance use disorder.Pharmacology, biochemistry, and behavior · 2024Review
- Tobacco Images Choice and Its Association with Craving and Dependence in Cigarette Smokers.bioRxiv : the preprint server for biology · 2024Article
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Towards neuromarkers for tailored smoking cessation treatments.Addiction neuroscience · 2023Article
- A Brief Introduction to Human Behavioral Pharmacology: Methods, Design Considerations and Ethics.Perspectives on behavior science · 2022Article
- Logical fallacies and misinterpretations that hinder progress in translational addiction neuroscience.Journal of the experimental analysis of behavior · 2022Article
- Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies.Journal of the experimental analysis of behavior · 2022Review
- Lack of effect of the nociceptin opioid peptide agonist Ro 64-6198 on pain-depressed behavior and heroin choice in rats.Drug and alcohol dependence · 2022Article
- Quantifying value-based determinants of drug and non-drug decision dynamics.Psychopharmacology · 2021Article
- A Critical Review of Alcohol Administration Guidelines in Laboratory Medication Screening Research: Is It Time to Include Treatment Seekers?Alcoholism, clinical and experimental research · 2021Review
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Contribution of alcohol- and cigarette-related cues to concurrent reinforcer choice in humans.Behavioural processes · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Individuals with cocaine use disorder chronically self-administer cocaine to the detriment of other rewarding activities, a phenomenon best modeled in laboratory drug-choice procedures. These procedures can evaluate the reinforcing effects of drugs versus comparably valuable alternatives under multiple behavioral arrangements and schedules of reinforcement. However, assessing drug-choice in treatment-seeking or abstaining humans poses unique challenges: for ethical reasons, these populations typically cannot receive active drugs during research studies. Researchers have thus needed to rely on alternative approaches that approximate drug-choice behavior or assess more general forms of decision-making, but whether these alternatives have relevance to real-world drug-taking that can inform clinical trials is not well-understood. In this mini-review, we (A) summarize several important modulatory variables that influence cocaine choice in nonhuman animals and non-treatment seeking humans; (B) discuss some of the ethical considerations that could arise if treatment-seekers are enrolled in drug-choice studies; (C) consider the efficacy of alternative procedures, including non-drug-related decision-making and 'simulated' drug-choice (a choice is made, but no drug is administered) to approximate drug choice; and (D) suggest opportunities for new translational work to bridge the current divide between preclinical and clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.