ArticleBMC medicine2015
How effective are common medications: a perspective based on meta-analyses of major drugs.
Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06665919 (Randomized Controlled Trial for Evaluating CYP2C19 Allele Genotype-guided Clopidogrel Treatment Outcomes in Real-world Practice After the ePCI), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial for Evaluating CYP2C19 Allele Genotype-guided Clopidogrel Treatment Outcomes in Real-world Practice After the ePCI
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Combined Cognitive Training and Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: A Systematic Review and Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Pooled it
- Comparing the evidential strength for psychotropic drugs: a Bayesian meta-analysis.Psychological medicine · 2021Pooled it
- Outcomes of psychological therapies for prisoners with mental health problems: A systematic review and meta-analysis.Journal of consulting and clinical psychology · 2017Pooled it
- Impact of the COVID-19 Pandemic on Parent, Child, and Family Functioning.Family process · 2022Trial
- The use of N-acetylcysteine in the prevention of hangover: a randomized trial.Scientific reports · 2021Trial
- Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.Nature medicine · 2017Trial
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Do antipsychotics work in people with schizophrenia? A review of outcomes and effect sizes.CNS spectrums · 2025Review
- [Placebo effect in the treatment with antidepressants : Implications for the scientific evaluation and clinical use of pharmaceutical treatments of depression].Der Nervenarzt · 2025Review
- The involvement of serotonin in major depression: nescience in disguise?Molecular psychiatry · 2024Article
- Identifying active ingredients in cognitive-behavioral therapies: What if we didn't?Behaviour research and therapy · 2023Article
- Clinical characteristics of children and adolescents with ADHD with or without methylphenidate prescription at their first diagnostic assessment.European archives of psychiatry and clinical neuroscience · 2022Article
- DrDimont: explainable drug response prediction from differential analysis of multi-omics networks.Bioinformatics (Oxford, England) · 2022Article
- Key concepts for informed health choices. 1.1: assumptions that treatments are safe or effective can be misleading.Journal of the Royal Society of Medicine · 2022Article
- StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials.Journal of medical Internet research · 2022Article
- Clinically Meaningful Benefit in Women with Hypoactive Sexual Desire Disorder Treated with Flibanserin.Sexual medicine · 2022Article
- Excess significance and power miscalculations in neurofeedback research.NeuroImage. Clinical · 2022Article
- Medicine and Phlebolymphology: Time to Change?Journal of clinical medicine · 2020Review
- Pharmacogenomics and Cardiovascular Disease: Where are We and Where do We go from Here?Arquivos brasileiros de cardiologia · 2020Article
- From digital hype to analogue reality: Universal simulation beyond the quantum and exascale eras.Journal of computational science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vastness of clinical data and the progressing specialization of medical knowledge may lead to misinterpretation of medication efficacy. To show a realistic perspective on drug efficacy we present meta-analyses on some of the most commonly used pharmacological interventions. For each pharmacological intervention we present statistical indexes (absolute risk or response difference, percentage response ratio, mean difference, standardized mean difference) that are often used to represent efficacy. We found that some of the medications have relatively low effect sizes with only 11 out of 17 of them showing a minimal clinically important difference. Efficacy was often established based on surrogate outcomes and not the more relevant patient-oriented outcomes. As the interpretation of the efficacy of medication is complex, more training for physicians might be needed to get a more realistic view of drug efficacy. That could help prevent harmful overtreatment and reinforce an evidence-based, but personalized medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.