Evidence map›Paper›PMID 26431883›Full record

ArticleEnvironment international2015

Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy.

Marie Lynn Miranda, Rebecca Anthopolos, Amy Wolkin, Heather M Stapleton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Marie Lynn MirandaSchool of Natural Resources and Environment, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mlmirand@umich.edu.
Rebecca AnthopolosSchool of Natural Resources and Environment, University of Michigan, Ann Arbor, MI 48109, USA.
Amy WolkinNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Heather M StapletonNicholas School of the Environment, Duke University, Durham, NC 27708, USA.
University of Michigan–Ann Arbor · USCenters for Disease Control and Prevention · USDuke University · US

Funding

Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
NIEHS NIH HHS R01 ES016099
6 · The paper itself

Abstract

backgroundPrevious research has linked polybrominated diphenyl ether (PBDE) exposure to poor birth outcomes and altered thyroid hormone levels.

objectivesWe examined whether maternal PBDE serum levels were associated with infant birth weight (g), head circumference (cm), birth length (cm), and birth weight percentile for gestational age. We explored the potential for a mediating role of thyroid hormone levels.

methodsDuring 2008-2010, we recruited 140 pregnant women in their third trimester as part of a larger clinical obstetrics study known as Healthy Pregnancy, Healthy Baby. Blood samples were collected during a routine prenatal clinic visit. Serum was analyzed for PBDEs, phenolic metabolites, and thyroid hormones. Birth outcome information was abstracted from medical records.

resultsIn unadjusted models, a two-fold increase in maternal BDE 153 was associated with an average decrease in head circumference of 0.32cm (95% CI: -0.53, -0.12); however, this association was attenuated after control for maternal risk factors. BDE 47 and 99 were similarly negatively associated but with 95% confidence intervals crossing the null. Associations were unchanged in the presence of thyroid hormones.

conclusionsOur data suggest a potential deleterious association between maternal PBDE levels and infant head circumference; however, confirmatory studies are needed in larger sample sizes. A mediating role of thyroid hormones was not apparent.

Indexed as

AdultBirth WeightEnvironmental PollutantsFemaleGestational AgeHalogenated Diphenyl EthersHumansInfantMaternal ExposurePolybrominated BiphenylsPregnancyPregnancy OutcomePregnancy Trimester, ThirdThyroid HormonesYoung Adult2,2',4,4'-tetrabromodiphenyl etherEnvironmental PollutantsHalogenated Diphenyl Ethershexabrominated diphenyl ether 153Polybrominated BiphenylsThyroid HormonesBirth outcomesBirth weightHead circumferenceInfant lengthPolybrominated diphenyl ethersThyroid hormone

Identifiers

PMID26431883
PMCPMC4648648
OpenAlexW1754080997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.