Evidence map›Paper›PMID 26431758›Full record

ReviewSleep medicine2016

Association between sleep deficiency and cardiometabolic disease: implications for health disparities.

Vittobai Rashika Rangaraj, Kristen L Knutson

Abstract readReview
In one paragraph

Review in Sleep medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 118 citations in OpenAlex.

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  13. The association between sleep fragmentation and incident atrial fibrillation: a prospective cohort study in a community population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
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  18. The Role of Sleep in Cardiovascular Disease.Current atherosclerosis reports · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vittobai Rashika RangarajDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Kristen L KnutsonDepartment of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: kknutson@medicine.bsd.uchicago.edu.
University of Chicago · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian DisruptionR01OH009482 · OH · UNIVERSITY OF CHICAGO · PI VAN CAUTER, EVE · 2009 to 2013
$3.4M
Home sleep and circadian phase: mediators of racial disparities in diabetes riskR01DK095207 · NIDDK · UNIVERSITY OF CHICAGO · PI KNUTSON, KRISTEN · 2012 to 2016
$2.1M
NCATS NIH HHS UL1 TR000430NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK095207NIDDK NIH HHS R01DK095207NIOSH CDC HHS R01 OH009482NIOSH CDC HHS R01OH009482
6 · The paper itself

Abstract

backgroundCardiometabolic diseases, which include obesity, diabetes, hypertension, and cardiovascular disease, are associated with reduced quality of life and reduced life expectancy. Unfortunately, there are racial/ethnic and socioeconomic disparities associated with these diseases such that minority populations, such as African Americans and Hispanics, and those of lower socioeconomic status, experience a greater burden. Several reports have indicated that there are differences in sleep duration and quality that mirror the disparities in cardiometabolic disease. The goal of this paper is to review the association between sleep and cardiometabolic disease risk because of the possibility that suboptimal sleep may partially mediate the cardiometabolic disease disparities.

methodsWe review both experimental studies that have restricted sleep duration or impaired sleep quality and examined biomarkers of cardiometabolic disease risk, including glucose metabolism and insulin sensitivity, appetite regulation and food intake, and immune function. We also review observational studies that have examined the association between habitual sleep duration and quality, and the prevalence or risk of obesity, diabetes, hypertension, and cardiovascular disease.

conclusionMany experimental and observational studies do support an association between suboptimal sleep and increased cardiometabolic disease risk.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHealth Status DisparitiesHumansMaleObesityRisk FactorsSleep Wake DisordersDiabetesEpidemiologyHypertensionInflammation

Identifiers

PMID26431758
PMCPMC4758899
OpenAlexW2049504682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.