Evidence map›Paper›PMID 26431698›Full record

SynthesisObesity surgery2016

The Impact of Bariatric Surgery on Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis.

Daniel Skubleny, Noah J Switzer, Richdeep S Gill, Mark Dykstra, Xinzhe Shi, Margaret A Sagle, Christopher de Gara, Daniel W Birch, Shahzeer Karmali

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 7 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151459 naunknown statusstarted 2019, after this paper: background citation

Effect of Laparoscopic Sleeve Gastrectomy (LSG) on Live Birth Rate of Offspring in Polycystic Ovarian Syndrome (PCOS) Patients With Severely Obese

Ran2019Enrolled18Registered outcomes3Posted comparisons0ConditionsLaparoscopic Sleeve Gastrectomy, Polycystic Ovary Syndrome, Severe ObesityArmsMetformin
Open the trial in the graph
NCT05646199 phase2 / phase3unknown statusnot on this mapstarted 2025, after this paper: background citation

The Effect of Semaglutide Compared to Metformin in Obese Women With Polycystic Ovary Syndrome (PCOS): a Randomised Controlled Study (Semaglutide-PCOS Trial).

TypeinterventionalSponsorUniversity of HullRan2025 to 2025Enrolled60ConditionsPolycystic Ovary SyndromeArmsMetformin, Semaglutide Injectable Product
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 7 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The Impact of Bariatric Surgery Compared to Metformin Therapy on Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Pooled it
  7. Pooled it
  8. Trial
  9. Observational
  10. Article
  11. Review
  12. Observational
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Precision Medicine in Bariatric Procedures.Gastrointestinal endoscopy clinics of North America · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniel SkublenyFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Noah J SwitzerDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. nswitzer@ualberta.ca.ORCID http://orcid.org/0000-0002-9273-1008
Richdeep S GillDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Mark DykstraDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Xinzhe ShiCentre for the Advancement of Minimally Invasive Surgery (CAMIS), Royal Alexandra Hospital, Edmonton, Canada.
Margaret A SagleDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.
Christopher de GaraDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Daniel W BirchDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Shahzeer KarmaliDepartment of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
University of Alberta · CARoyal Alexandra Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bariatric surgery has been proven to be a successful management strategy for morbid obesity, but limited studies exist on its effect on polycystic ovary syndrome (PCOS). A comprehensive search of electronic databases was completed. Meta-analysis was performed on PCOS, hirsutism, and menstrual irregularity outcomes following bariatric surgery. Thirteen primary studies involving a total of 2130 female patients were identified. The incidence of PCOS preoperatively was 45.6 %, which significantly decreased to 6.8 % (P < 0.001) and 7.1 % (P < 0.0002) at 12-month follow-up and study endpoint, respectively. The incidences of preoperative menstrual irregularity and hirsutism both significantly decreased at 12-month and at study end follow-up. Bariatric surgery effectively attenuates PCOS and its clinical symptomatology including hirsutism and menstrual irregularity in severely obese women.

Indexed as

Bariatric SurgeryFemaleHirsutismHumansMenstruation DisturbancesObesity, MorbidPolycystic Ovary SyndromeBariatric surgeryObesityPolycystic ovary syndrome

Identifiers

PMID26431698
OpenAlexW1876350695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.