ArticlePloS one2015
Phylogenesis and Biological Characterization of a New Glucose Transporter in the Chicken (Gallus gallus), GLUT12.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- A perception that the feed grain basis of reduced-crude protein diets modifies the anabolic impact of insulin on the growth performance of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Glycation resistance and life-history traits: lessons from non-conventional animal models.Biology letters · 2024Review
- Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds.Integrative zoology · 2022Article
- Sequencing refractory regions in bird genomes are hotspots for accelerated protein evolution.BMC ecology and evolution · 2021Article
- Progress towards reduced-crude protein diets for broiler chickens and sustainable chicken-meat production.Journal of animal science and biotechnology · 2021Review
- Early Growth and Protein-Energy Metabolism in Chicken Lines Divergently Selected on Ultimate pH.Frontiers in physiology · 2021Article
- An Evolutionary Remedy for an Abominable Physiological Mystery: Benign Hyperglycemia in Birds.Journal of molecular evolution · 2020Article
- Inter genotype differences in expression of genes involved in glucose metabolism in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks.Molecular biology reports · 2020Article
- Early-life conditioning strategies to reduce dietary phosphorus in broilers: underlying mechanisms.Journal of nutritional science · 2020Article
- Delayed access to feed alters expression of genes associated with carbohydrate and amino acid utilization in newly hatched broiler chicks.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Integrative analysis of transcriptomic data related to the liver of laying hens: from physiological basics to newly identified functions.BMC genomics · 2019Article
- Expression of glucose transporters SLC2A1, SLC2A8, and SLC2A12 in different chicken muscles during ontogenesis.Journal of animal science · 2018Article
- Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases.International journal of endocrinology · 2018Review
- Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism.Poultry science · 2017Article
- Kinetics of expression of genes involved in glucose metabolism after the last meal in overfed mule ducks.Molecular and cellular biochemistry · 2017Article
- Avian and Mammalian Facilitative Glucose Transporters.Microarrays (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, insulin-sensitive GLUTs, including GLUT4, are recruited to the plasma membrane of adipose and muscle tissues in response to insulin. The GLUT4 gene is absent from the chicken genome, and no functional insulin-sensitive GLUTs have been characterized in chicken tissues to date. A nucleotide sequence is predicted to encode a chicken GLUT12 ortholog and, interestingly, GLUT12 has been described to act as an insulin-sensitive GLUT in mammals. It encodes a 596 amino acid protein exhibiting 71% identity with human GLUT12. First, we present the results of a phylogenetic study showing the stability of this gene during evolution of vertebrates. Second, tissue distribution of chicken SLC2A12 mRNA was characterized by RT-PCR. It was predominantly expressed in skeletal muscle and heart. Protein distribution was analysed by Western blotting using an anti-human GLUT12 antibody directed against a highly conserved region (87% of identity). An immuno-reactive band of the expected size (75kDa) was detected in the same tissues. Third a physiological characterization was performed: SLC2A12 mRNA levels were significantly lowered in fed chickens subjected to insulin immuno-neutralization. Finally, recruitment of immuno-reactive GLUT12 to the muscle plasma membrane was increased following 1h of intraperitoneal insulin administration (compared to a control fasted state). Thus insulin administration elicited membrane GLUT12 recruitment. In conclusion, these results suggest that the facilitative glucose transporter protein GLUT12 could act in chicken muscle as an insulin-sensitive transporter that is qualitatively similar to GLUT4 in mammals.
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