Evidence map›Paper›PMID 26431485›Full record

ArticleInvestigative ophthalmology & visual science2015

Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis.

Eda Altiok, Tatiana Ecoiffier, Roberto Sessa, Don Yuen, Sammy Grimaldo, Colin Tran, David Li, Michael Rosner, Narae Lee, Toshimitsu Uede and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Central conducting lymphatic anomaly: from bench to bedside.The Journal of clinical investigation · 2024
    Review
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  8. TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis.Journal of cellular and molecular medicine · 2019
    Article
  9. Article
  10. Angiopoietin-2 Blockade Promotes Survival of Corneal Transplants.Investigative ophthalmology & visual science · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Eda AltiokVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Tatiana EcoiffierVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Roberto SessaVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Don YuenVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Sammy GrimaldoVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Colin TranVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
David LiVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Michael RosnerVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Narae LeeVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
Toshimitsu UedeInstitute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Lu ChenVision Science Graduate Program, University of California, Berkeley, California, United States 2Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California, United States.
University of California, Berkeley · USHokkaido University · JP

Funding

Molecular Regulation of Lymphangiogenesis in Corneal AlloimmunityR01EY017392 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, LU · 2007 to 2020
$5.7M
NEI NIH HHS R01 EY017392
6 · The paper itself

Abstract

purposeWe recently reported that corneal lymphatic vessels develop integrin alpha-9 (Itga-9)-positive valves during inflammatory lymphangiogenesis. The purpose of this study was to further investigate the role of Itga-9 in corneal lymphatic valve formation in vivo and lymphatic endothelial cell (LEC) functions in vitro.

methodsStandard murine suture placement model was used to study the effect of Itga-9 blockade on lymphatic valve formation in vivo using Itga-9 neutralizing antibody. Whole-mount corneas were harvested for immunofluorescent microscopic analysis. Additionally, human LEC culture system was used to examine the effect of Itga-9 gene knockdown on cell functions using small interfering RNAs (siRNAs).

resultsItga-9 blockade in vivo significantly reduced the number of lymphatic valves formed in the inflamed cornea. Moreover, Itga-9 gene knockdown in human LECs suppresses cell functions of proliferation, adhesion, migration, and tube formation.

conclusionsItga-9 is critically involved in corneal lymphatic valve formation. Further investigation of the Itga-9 pathway may provide novel strategies to treat lymphatic-related diseases occurring both inside and outside the eye.

Indexed as

AnimalsCells, CulturedCorneal NeovascularizationDisease Models, AnimalEndothelial CellsIntegrin alpha ChainsLymphangiogenesisLymphatic VesselsMaleMiceMice, Inbred BALB Cintegrin alpha9Integrin alpha Chains

Identifiers

PMID26431485
PMCPMC4911102
OpenAlexW1868431276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.