Evidence map›Paper›PMID 26431374›Full record

ArticleMetabolic syndrome and related disorders2015

Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians.

Catherine Kim, Shengchun Kong, Ronald M Krauss, Frank Z Stanczyk, Srinivasa T Reddy, Belinda L Needham, Alka M Kanaya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic syndrome and related disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Catherine Kim1 Department of Medicine, University of Michigan , Ann Arbor, Michigan.
Shengchun Kong3 Department of Statistics, Purdue University , West Lafayette, Indiana.
Ronald M Krauss4 Children's Hospital Oakland Research Institute , Oakland, California.
Frank Z Stanczyk5 Departments of Obstetrics and Gynecology, University of Southern California , Los Angeles, California.
Srinivasa T Reddy6 Department of Medicine, University of California , Los Angeles, Los Angeles, California.
Belinda L Needham7 Department of Epidemiology, University of Michigan , Ann Arbor, Michigan.
Alka M Kanaya8 Department of Medicine, University of California , San Francisco, California.
University of Michigan · USPurdue University West Lafayette · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
Metabolic Syndrome and Atherosclerosis in South AsiansK23HL080026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2006 to 2008
$442k
NCATS NIH HHS UL1 TR001108NCRR NIH HHS UL1 RR024131-01NHLBI NIH HHS K23 HL080026NHLBI NIH HHS K24 HL112827NHLBI NIH HHS K24HL112827NHLBI NIH HHS R01 HL093009NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

backgroundEstradiol, testosterone (T), and sex hormone binding globulin (SHBG) levels are associated with lipid subfractions in men and women. Our objective was to determine if associations are independent from adipose tissue area among Asian Indians.

methodsWe used data from 42 women and 57 Asian Indian men who did not use exogenous steroids or lipid-lowering medications. Lipoprotein subfractions including low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL), and intermediate density lipoprotein (IDL) were assessed by ion mobility spectrometry. Intra-abdominal adiposity was assessed by computed tomography. Multivariable regression models estimated the association between sex hormones with lipoprotein subfractions before and after adjustment for adiposity.

resultsAmong women, lower logSHBG levels were associated with smaller logLDL particle size and higher logtriglycerides, logVLDL, and logIDL, although these associations were attenuated with adjustment for visceral adiposity in particular. Among women, lower logSHBG levels was significantly associated with lower logmedium LDL and logsmall LDL concentrations even after consideration of visceral and hepatic adiposity and insulin resistance as represented by the homeostasis model assessment of insulin resistance (HOMA-IR). Among men, lower logSHBG was also associated with smaller logLDL peak diameter size and higher logtriglycerides and logVLDL, even after adjustment for HOMA-IR and adiposity. Relationships between sex steroids and lipid subfractions were not significant among women. Among men, higher total testosterone was associated with higher logHDL and logLDL particle size, and lower logtriglycerides and logVLDL, but these associations were partially attenuated with adjustment for adiposity and HOMA-IR.

conclusionsAmong Asian Indians, SHBG is associated with more favorable lipid subfraction concentrations, independent of hepatic and visceral fat.

Indexed as

Asian PeopleAdiposityAgedAged, 80 and overBiomarkersBlood GlucoseCholesterolCholesterol, LDLCholesterol, VLDLEstradiolFemaleGonadal Steroid HormonesHealth StatusHumansIndiaInsulinBiomarkersBlood GlucoseCholesterolCholesterol, LDLCholesterol, VLDLEstradiolGonadal Steroid HormonesInsulinLipidslipoprotein cholesterolLipoproteinsSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID26431374
PMCPMC4696444
OpenAlexW2174877348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.