SynthesisPloS one2015
Risk Factors for Central Lymph Node Metastasis in CN0 Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 9 of them syntheses that pooled it.
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Who cites it
91 citing papers in PubMed, 9 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Risk prediction model for cervical lymph node metastasis of papillary thyroid microcarcinoma: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association of BRAFInternational journal of molecular sciences · 2022Pooled it
- Hashimoto's Thyroiditis: A "Double-Edged Sword" in Thyroid Carcinoma.Frontiers in endocrinology · 2022Pooled it
- Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis.World journal of surgery · 2021Pooled it
- The Differences Between Multifocal and Unifocal Papillary Thyroid Carcinoma in Unilateral Lobe: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy.Frontiers in oncology · 2020Pooled it
- Clinicopathological Risk Factors for Distant Metastasis in Differentiated Thyroid Carcinoma: A Meta-analysis.World journal of surgery · 2018Pooled it
- Association of diabetes mellitus with thyroid cancer risk: A meta-analysis of cohort studies.Medicine · 2017Pooled it
- The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Preoperative predictors of occult central lymph node metastasis in clinically node-negative papillary thyroid carcinoma: a common data model-based retrospective cohort study.Annals of surgical treatment and research · 2026Article
- Association between ultrasound radiomics features and central lymph node metastasis in patients with papillary thyroid carcinoma.American journal of cancer research · 2026Article
- Prognostic factors evaluated in differentiated thyroid carcinomas.Endocrine connections · 2026Review
- Preoperative prediction of central lymph node metastasis in clinically lymph node negative papillary thyroid microcarcinoma: a nomogram based on clinical and ultrasound features.BMC medical imaging · 2025Article
- The central lymph node dissection using carbon nanoparticle in transoral vestibular approach endoscopic thyroid surgery.Scientific reports · 2025Article
- Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients.Scientific reports · 2025Article
- Clinical performance of a machine learning-based model for detecting lymph node metastasis in papillary thyroid carcinoma: A multicenter study.International journal of surgery (London, England) · 2025Article
- Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features.BMC cancer · 2025Article
- CT radiomics analysis facilitates preoperative risk stratification of central lymph node metastasis in papillary thyroid cancer: a multicenter study.Frontiers in oncology · 2025Article
- Development and validation of a risk score model for patient stratification and personalized management of papillary thyroid cancer.Gland surgery · 2024Article
- Prediction of lateral neck metastasis in patients with papillary thyroid cancer with suspicious lateral lymph ultrasonic imaging based on central lymph node metastasis features.Oncology letters · 2024Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral lymph node metastasis (CLNM) is common in papillary thyroid carcinoma (PTC). Prophylactic central lymph node dissection (PCLND) for patients with clinically negative central compartment lymph nodes (CN0) remains controversial. The phrase "clinically negative" is used to indicate that patients exhibited no clinical evidence of CLNM by ultrasonography (US) or computerized tomography (CT) preoperatively. In this study, we analyze the risk factors for CLNM in CN0 patients.
methodsThe PUBMED and SCIE databases were systematically searched for works published through January 31, 2015. All of the patients included in this study underwent thyroidectomy+PCLND. Revman 5.3 software was used to analyze the data.
resultsTwenty studies and 9084 patients were included in this meta-analysis. The following variables were associated with an increased risk of CLNM in CN0 patients: age < 45 years (OR = 1.59, 95% CI = 1.42-1.78, p<0.00001), male sex (OR = 1.95, 95% CI = 1.63-2.32, p<0.00001), multifocality (OR = 1.43, 95% CI = 1.22-1.67, p<0.00001), tumor size > 2 cm for PTC patients (OR = 2.98, 95% CI 2.08-4.28, p<0.00001) or tumor size > 0.5 cm for papillary thyroid microcarcinoma (PTMC) patients (OR = 2.30, 95% CI = 1.71-3.09, p<0.00001), location of the primary tumor in the central area and low pole (OR = 1.86, 95% CI = 1.48-2.33, p<0.00001), lymphovascular invasion (OR = 4.35, 95% CI = 2.24-8.46, p<0.0001), extrathyroidal extension (OR = 2.27, 95% CI = 1.76-2.94, p<0.00001), and capsular invasion (OR = 1.72, 95% CI = 1.39-2.41, p<0.00001). PTC (tumor size > 1 cm) exhibited a higher risk factor associated with CLNM than PTMC (tumor size < 1 cm) (OR = 2.83, 95% CI = 2.15-3.72, p<0.00001). Bilateral tumors (OR = 1.21, 95% CI = 0.92-1.58, p = 0.17) and lymphocytic thyroiditis (OR = 0.88, 95% CI = 0.71-1.09, p = 0.25) had no association with CLNM in CN0 patients.
conclusionsOur systematic review identified several clinical features associated with CLNM in CN0 patients, including age, sex, multifocality, size, location, lymphovascular invasion, capsular invasion, and extrathyroidal extension. These factors should guide the application of PCLND in CN0 patients.
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