Evidence map›Paper›PMID 26431192›Full record

ArticleJournal of hypertension2015

Incidence and predictors of hypertension in adults with HIV-initiating antiretroviral therapy in south-western Uganda.

Samson Okello, Michael Kanyesigye, Winnie R Muyindike, Brian Herb Annex, Peter W Hunt, Sebastien Haneuse, Mark Jacob Siedner

Abstract read
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In one paragraph

Article in Journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  11. Physical activity and hypertension amongst HIV-positive and HIV-negative populations in rural South Africa.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Samson OkelloaDepartment of Internal Medicine bImmune Suppression Syndrome Clinic, Mbarara Regional Referral Hospital, Mbarara, Uganda cThe Robert M. Berne Cardiovascular Research Center & Division of Cardiovascular Medicine, Department of Medicine, University of Virginia, Charlottesville, Virginia dDivision of HIV/AIDS, Department of Medicine, University of California, San Francisco, California eDepartment of Epidemiology fDepartment of Biostatistics, Harvard T.H Chan School of Public Health gDepartment of Medicine and Center for Global Health, Massachusetts General Hospital hHarvard Medical School, Boston, Massachusetts, USA.
Michael Kanyesigye
Winnie R Muyindike
Brian Herb Annex
Peter W Hunt
Sebastien Haneuse
Mark Jacob Siedner
Harvard University · USMbarara National Referral Hospital · UGDivision of Chemistry · USMbarara University of Science and Technology · UGUniversity of Virginia · US

Funding

Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
Epidemiology of atherosclerosis among older-age individuals with HIV in UgandaR21HL124712 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2014 to 2015
$332k
NHLBI NIH HHS R21 HL124712NIMH NIH HHS K23 MH099916PHS HHS K23099916
6 · The paper itself

Abstract

objectiveThe successful scale-up of antiretroviral therapy (ART) in sub-Saharan Africa has led to increasing life expectancy, and thus increased risk of hypertension. We aimed to describe the incidence and predictors of hypertension in HIV patients receiving ART at a publicly funded clinic in rural Uganda.

methodsWe abstracted data from medical records of adult patients who initiated ART at an HIV clinic in south-western Uganda during 2010-2012. We defined hypertension as at least two consecutive clinical visits, with a SBP at least 140 mmHg and/or SBP of at least 90 mmHg, or prescription for an antihypertensive medication. We calculated the incidence of hypertension and fit multivariable Cox proportional-hazards models to identify predictors of hypertension.

resultsA total of 3389 patients initiated ART without a prior diagnosis of hypertension during the observation period. Over 3990 person-years of follow-up, 445 patients developed hypertension, for a crude incidence of 111.5/1000 (95% confidence interval 101.9-121.7) person-years. Rates were highest among men aged at least 40 years (158.8 per/1000 person-years) and lowest in women aged 30-39 years (80/1000 person-years). Lower CD4 cell count at ART initiation, as well as traditional risk factors including male sex, increasing age, and obesity, were independently associated with hypertension.

conclusionWe observed a high incidence of hypertension in HIV-infected persons on ART in rural Uganda, and increased risk with lower nadir CD4 cell counts. Our findings call for increased attention to screening of and treatment for hypertension, along with continued prioritization of early ART initiation.

Indexed as

HIV InfectionsHypertensionAdultAnti-Retroviral AgentsFemaleHumansIncidenceMaleRisk FactorsUgandaAnti-Retroviral Agents

Identifiers

PMID26431192
PMCPMC4700387
OpenAlexW2429410418

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.