Evidence map›Paper›PMID 26431178›Full record

ArticleCell stem cell2015

Moving Toward the Ground State.

Ishan Kumar, Natalia Ivanova

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ishan KumarYale Stem Cell Center and Department of Genetics, Yale University, 10 Amistad Street, New Haven, CT 06520, USA.
Natalia IvanovaYale Stem Cell Center and Department of Genetics, Yale University, 10 Amistad Street, New Haven, CT 06520, USA. Electronic address: natalia.ivanova@yale.edu.

Funding

Epigenetic control of the pluripotent state by chromatin-associated factor Dppa2R01GM105772 · NIGMS · YALE UNIVERSITY · PI IVANOVA, NATALIA B · 2014 to 2018
$1.6M
NIGMS NIH HHS R01 GM105772
6 · The paper itself

Abstract

Transferring mouse ESCs to a media supplemented with Mek and Gsk3β inhibitors (2i) provokes marked transcriptional and epigenetic changes, embodying a shift toward ground-state pluripotency. In this issue of Cell Stem Cell, Kolodziejczyk et al. (2015) examine population structures of ESCs while Galonska et al. (2015) unravel the mechanisms underlying regulatory network rewiring during 2i-mediated reprogramming.

Indexed as

Epigenesis, GeneticTranscriptomeAnimalsMouse Embryonic Stem CellsRNARNA

Identifiers

PMID26431178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.