Evidence map›Paper›PMID 26431116›Full record

ReviewAlcoholism, clinical and experimental research2015

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.

Angela R Ozburn, Aaron J Janowsky, John C Crabbe

Abstract readComparative StudyReview
In one paragraph

Review in Alcoholism, clinical and experimental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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  12. Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Angela R OzburnResearch & Development Service, Portland VA Medical Center, Portland, Oregon.
Aaron J JanowskyResearch & Development Service, Portland VA Medical Center, Portland, Oregon.
John C CrabbeResearch & Development Service, Portland VA Medical Center, Portland, Oregon.
Portland VA Medical Center · USOregon Health & Science University · US

Funding

Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Suzanne S. Fei · 2006 to 2026
$34.5M
Traditional Service Core [Translational Service Core (TSC)]P50DA018165 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BELKNAP, JOHN K · 2006 to 2016
$13.0M
Selective Breeding for Drinking in the Circadian DarkU01AA013519 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angela Renee Ozburn · 2001 to 2026
$10.9M
THERMAL AND METABOLIC DYSFUNCTION DURING WITHDRAWALP50AA010760 · NIAAA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI CRABBE, JOHN C. · 1996 to 2005
$10.7M
Mouse Genetic Models for Alcohol ResearchR24AA020245 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2011 to 2020
$2.3M
Pharmacogenetic manipulation of brain regions to reduce alcohol binge drinkingIK2BX002488 · VA · PORTLAND VA MEDICAL CENTER · PI OZBURN, ANGELA RENEE · 2015 to 2020
–
Trace amine receptor-mediated methamphetamine response in brainI01BX002758 · VA · PORTLAND VA MEDICAL CENTER · PI JANOWSKY, AARON J. · 2016 to 2019
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Genetic Models of AlcoholismI01BX000313 · VA · PORTLAND VA MEDICAL CENTER · PI CRABBE, JOHN C. · 2009 to 2019
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BLRD VA I01 BX000313BLRD VA I01 BX002758BLRD VA IK2 BX002488NIAAA NIH HHS AA020245NIAAA NIH HHS AA10760NIAAA NIH HHS AA13519NIAAA NIH HHS P50 AA010760NIAAA NIH HHS P60 AA010760NIAAA NIH HHS R24 AA020245NIAAA NIH HHS U01 AA013519NIDA NIH HHS P50 DA018165
6 · The paper itself

Abstract

backgroundAlcohol abuse is comorbid with abuse of many other drugs, some with similar pharmacology and others quite different. This leads to the hypothesis of an underlying, unitary dysfunctional neurobiological basis for substance abuse risk and consequences.

methodsIn this review, we discuss commonalities and distinctions of addiction to alcohol and other drugs. We focus on recent advances in preclinical studies using rodent models of drug self-administration.

resultsWhile there are specific behavioral and molecular manifestations common to alcohol, psychostimulant, opioid, and nicotine dependence, attempts to propose a unifying theory of the addictions inevitably face details where distinctions are found among classes of drugs.

conclusionsFor alcohol, versus other drugs of abuse, we discuss and compare advances in: (i) neurocircuitry important for the different stages of drug dependence; (ii) transcriptomics and genetical genomics; and (iii) enduring effects, noting in particular the contributions of behavioral genetics and animal models.

Indexed as

AlcoholismAnimalsBehavior, AddictiveDisease Models, AnimalGenomicsHumansNeural PathwaysSelf AdministrationSubstance-Related DisordersTranscriptomeAddictionAlcoholAnimal ModelsCocaineDrugs of Abuse

Identifiers

PMID26431116
PMCPMC4594192
OpenAlexW2169466291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.