Evidence map›Paper›PMID 26430892›Full record

ArticlePloS one2015

Albuminuria as a Risk Factor for Anemia in Chronic Kidney Disease: Result from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).

Ji Suk Han, Mi Jung Lee, Kyoung Sook Park, Seung Hyeok Han, Tae-Hyun Yoo, Kook-Hwan Oh, Sue Kyung Park, Joongyub Lee, Young Youl Hyun, Wookyung Chung and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Ji Suk HanDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Mi Jung LeeDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Kyoung Sook ParkDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Seung Hyeok HanDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Tae-Hyun YooDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University, Seoul, Korea.
Sue Kyung ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Joongyub LeeMedical Research Collaborating Center, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea.
Young Youl HyunDepartment of Internal Medicine, Kangbuk Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
Wookyung ChungDepartment of Internal Medicine, Gachon University, Gil Hospital, Incheon, Korea.
Yeong Hoon KimDepartment of Internal Medicine, Inje University, Pusan Paik Hospital, Busan, Korea.
Curie AhnDepartment of Internal Medicine, Seoul National University, Seoul, Korea.
Kyu Hun ChoiDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
Yonsei University · KRSeoul National University · KRDeleted InstitutionInje University Busan Paik Hospital · KRSeoul National University Hospital · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnemia is a common complication among patients with chronic kidney disease (CKD), and it is associated with unfavorable clinical outcomes in patients with CKD independent of the estimated glomerular filtration rate (eGFR). We assessed the association of the urinary albumin-to-creatinine ratio (ACR) and eGFR with anemia in CKD patients.

methodsWe conducted a cross-sectional study using baseline data from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD). Multiple regression analysis was performed to identify the independent association of albuminuria with anemia. Furthermore, odds ratios for anemia were calculated by cross-categorization of ACR and eGFR.

resultsAmong 1,456 patients, the mean age was 53.5 ± 12.4 years, and the mean eGFR and ACR were 51.9 ± 30.5 mL/min per 1.73 m2 and 853.2 ± 1,330.3 mg/g, respectively. Anemia was present in 644 patients (40.5%). Multivariate analysis showed that the odds ratio of anemia increased according to ACR levels, after adjusting for age, sex, eGFR, body mass index, pulse pressure, cause of CKD, use of erythropoiesis stimulating agents, serum calcium and ferritin (ACR < 30 mg/g as a reference group; 30-299 mg/g, adjusted odds ratio (OR) = 1.43, 95% confidence interval (CI) = 0.88-2.33; ≥300 mg/g, adjusted OR = 1.86, 95% CI = 1.12-3.10). In addition, graded associations were observed in cross-categorized groups of a higher ACR and eGFR compared to the reference group with an ACR <30 mg/g and eGFR ≥60 mL/min per 1.73 m2.

conclusionThe present study demonstrated that albuminuria was a significant risk factor for anemia in CKD patients independent of the eGFR.

Indexed as

AdultAgedAlbuminuriaAnemiaCohort StudiesHumansKidney Failure, ChronicMiddle AgedRepublic of KoreaRisk FactorsTreatment Outcome

Identifiers

PMID26430892
PMCPMC4592200
OpenAlexW2097672209

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.