ArticleAmerican journal of human genetics2015
Imputation of KIR Types from SNP Variation Data.
Article in American journal of human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness.Frontiers in immunology · 2019Trial
- Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Genome medicine · 2018Trial
- Graph-KIR: graph-based KIR copy number estimation and allele calling using short-read sequencing data.Bioinformatics (Oxford, England) · 2026Article
- A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long-Read Data.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight.PLoS genetics · 2026Article
- A machine-learning method for biobank-scale genetic prediction of blood group antigens.PLoS computational biology · 2024Article
- Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes.Frontiers in immunology · 2024Article
- Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections.Immunogenetics · 2023Review
- Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.Genome research · 2023Article
- Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.Nature communications · 2022Article
- Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health.The journal of allergy and clinical immunology. In practice · 2022Article
- Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL.Blood advances · 2022Article
- Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method.Cell genomics · 2022Article
- Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1.PLoS computational biology · 2022Article
- KIR gene content imputation from single-nucleotide polymorphisms in the Finnish population.PeerJ · 2022Article
- Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes.Frontiers in genetics · 2022Article
- The role of critical immune genes in brain disorders: insights from neuroimaging immunogenetics.Brain communications · 2022Article
- HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases.Seminars in immunopathology · 2022Review
- Killer-cell immunoglobulin-like receptor/human leukocyte antigen-C combination and 'great obstetrical syndromes' (Review).Experimental and therapeutic medicine · 2021Review
- HIV-1 and human genetic variation.Nature reviews. Genetics · 2021Review
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 7 countries.
Funding
Abstract
Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing expensive and time consuming. Consequently, despite their importance, KIRs have been little studied in large cohorts. Statistical imputation methods developed for other complex loci (e.g., human leukocyte antigen [HLA]) on the basis of SNP data provide an inexpensive high-throughput alternative to direct laboratory typing of these loci and have enabled important findings and insights for many diseases. We present KIR∗IMP, a method for imputation of KIR copy number. We show that KIR∗IMP is highly accurate and thus allows the study of KIRs in large cohorts and enables detailed investigation of the role of KIRs in human disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.