ArticlePLoS pathogens2015
Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Is the developmental stage important for the plasticity of transgenerational immune priming?Biology open · 2026Article
- Article
- Lack of Tolerance Development Following Oral Exposure Tosublethal Cry1 and Vip3Aa Proteins inInsects · 2026Article
- Rethinking Disease Control in Aquaculture Invertebrates: Harnessing Innate Immunity in Molluscs and Crustaceans.Pathogens (Basel, Switzerland) · 2026Review
- Recent insights in the development and functions of insect hemocytes.Current opinion in insect science · 2026Review
- Article
- Immune priming of honey bees protects against a major microsporidian pathogen.Pest management science · 2025Article
- Current insights into insect immune memory.eLife · 2025Review
- Long-Chain Hydrocarbons in the Mucous Layer of theACS omega · 2025Article
- The integral role of the Black Soldier fly,Frontiers in microbiomes · 2025Review
- Multigenerational inheritance of parasitic stress memory inEnvironmental epigenetics · 2025Article
- Evidence for trans-generational immune priming againstFrontiers in immunology · 2025Article
- Juvenile responses to immune challenges are not carried through to subsequent life stages in an insect.Scientific reports · 2024Article
- Infection risk by oral contamination does not induce immune priming in the mealworm beetle (Frontiers in immunology · 2024Article
- Preventing bacterial disease in poultry in the post-antibiotic era: a case for innate immunity modulation as an alternative to antibiotic use.Frontiers in immunology · 2023Review
- Molecular mechanisms of insect immune memory and pathogen transmission.PLoS pathogens · 2022Article
- Senescence of the immune defences and reproductive trade-offs in females of the mealworm beetle, Tenebrio molitor.Scientific reports · 2022Article
- Efficient Oral Priming ofVaccines · 2022Article
- Immunomodulatory potential of black soldier fly larvae: applications beyond nutrition in animal feeding programs.Translational animal science · 2022Article
- Fungal Priming: Prepare or Perish.Journal of fungi (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many vertebrates and invertebrates, offspring whose mothers have been exposed to pathogens can exhibit increased levels of immune activity and/or increased survival to infection. Such phenomena, called "Trans-generational immune priming" (TGIP) are expected to provide immune protection to the offspring. As the offspring and their mother may share the same environment, and consequently similar microbial threats, we expect the immune molecules present in the progeny to be specific to the microbes that immune challenged the mother. We provide evidence in the mealworm beetle Tenebrio molitor that the antimicrobial activity found in the eggs is only active against Gram-positive bacteria, even when females were exposed to Gram-negative bacteria or fungi. Fungi were weak inducers of TGIP while we obtained similar levels of anti-Gram-positive activity using different bacteria for the maternal challenge. Furthermore, we have identified an antibacterial peptide from the defensin family, the tenecin 1, which spectrum of activity is exclusively directed toward Gram-positive bacteria as potential contributor to this antimicrobial activity. We conclude that maternal transfer of antimicrobial activity in the eggs of T. molitor might have evolved from persistent Gram-positive bacterial pathogens between insect generations.
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