Evidence map›Paper›PMID 26430702›Full record

ArticleCell systems2015

Transcription Factor Activity Mapping of a Tissue-Specific

Lesley T MacNeil, Carles Pons, H Efsun Arda, Gabrielle E Giese, Chad L Myers, Albertha J M Walhout

Open access · bronzeAbstract read
In one paragraph

Article in Cell systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
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  5. A default silencing mechanism restrains stress-induced genes inbioRxiv : the preprint server for biology · 2025
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  9. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.bioRxiv : the preprint server for biology · 2025
    Article
  10. Unzipping the defense: a comprehensive review on bZIP transcription factors inFrontiers in cellular and infection microbiology · 2025
    Review
  11. Analysis ofComputational and structural biotechnology journal · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lesley T MacNeilProgram in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Carles PonsDepartment of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
H Efsun ArdaProgram in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Gabrielle E GieseProgram in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Chad L MyersDepartment of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Albertha J M WalhoutProgram in Systems Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · USUniversity of Minnesota · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Identifying transcription factor binding sites in the C. elegans genomeR01GM082971 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WALHOUT, A. J. MARIAN · 2008 to 2016
$5.8M
NIGMS NIH HHS R01 GM082971NIH HHS P40 OD010440
6 · The paper itself

Abstract

A wealth of physical interaction data between transcription factors (TFs) and DNA has been generated, but these interactions often do not have apparent regulatory consequences. Thus, equating physical interaction data with gene regulatory networks (GRNs) is problematic. Here, we comprehensively assay TF activity, rather than binding, to construct a network of gene regulatory interactions in the

Identifiers

PMID26430702
PMCPMC4584425
OpenAlexW1923774230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.