ReviewArchives of plastic surgery2015
Capsular Contracture after Breast Augmentation: An Update for Clinical Practice.
Review in Archives of plastic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 4 syntheses or guidelines pooled it, 331 citations in OpenAlex.
- The Role of Montelukast in the Prevention and Treatment of Capsular Contracture (Baker Grade III-IV) - A Systematic Review and Case Analysis.Aesthetic plastic surgery · 2026Pooled it
- Reverse Expansion Technique for Total Autologous and Hybrid Breast Reconstruction: A Systematic Review and a Meta-analysis.Aesthetic plastic surgery · 2026Pooled it
- Efficacy of antibiotic prophylaxis for reducing capsular contracture in prosthesis-based breast surgery: a systemic review and meta-analysis.Updates in surgery · 2024Pooled it
- From Case Reports to Molecular Insight: Examining the Outcomes and Underlying Mechanisms of Squamous Cell Carcinoma in Breast Implant Patients-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Scaffold-based breast conserving surgery in patients with non-malignant breast lesions: long-term follow-up of a first-in-human pilot study on the REGENERA™ biomimetic breast implant.Breast cancer (Tokyo, Japan) · 2026Trial
- Comparative clinical evaluation of breast augmentation using silicone foam coated implants and textured implants.Acta cirurgica brasileira · 2020Trial
- Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo.Advanced healthcare materials · 2026Review
- Clinical Management After Rupture of Silicone Gel-Filled Breast Implants in a Surgically Treated Cohort: A Retrospective Study.European journal of breast health · 2026Article
- Readability of Online Informed Consent Forms for Implant-Based Breast Augmentation Across 6 Languages: Cross-Sectional Study.JMIR formative research · 2026Article
- Changing Paradigms in Polyurethane-coated Breast Implant Surgery: A Bibliometric Analysis of 4 Decades of Clinical Practice.Plastic and reconstructive surgery. Global open · 2026Article
- Effects of Pentoxifylline on Peri-Implant Capsule Cellularity and Thickness: A Controlled Experimental Study in a Rat Silicone Implant Model.International journal of molecular sciences · 2026Article
- Does Patient History Influence Capsular Contracture? An Exploratory Analysis with Machine Learning.Aesthetic plastic surgery · 2026Article
- Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies.Medicina (Kaunas, Lithuania) · 2026Review
- Breast cancer: taxonomy, distribution analysis, risk factors, predictive biomarkers, and modern treatment method.Apoptosis : an international journal on programmed cell death · 2026Review
- Critical Considerations on Polyurethane-Coated Implants in Breast Reconstruction.Aesthetic surgery journal · 2026Article
- The Effects of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants in a Rat Prepectoral Reconstruction Model.Bioengineering (Basel, Switzerland) · 2026Article
- Understanding Capsular Contracture: Mechanisms, Management, and Patient Outcomes in Implant-based Breast Augmentation and Reconstruction.Plastic and reconstructive surgery. Global open · 2026Article
- Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation.Frontiers in toxicology · 2026Article
- Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good.npj biomedical innovations · 2026Review
- A Long-Term Single-Center Study: Motivations and Strategies in Implant Management for Breast Augmentation Revision Surgery.Aesthetic plastic surgery · 2025Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsular contracture is the most common complication following implant based breast surgery and is one of the most common reasons for reoperation. Therefore, it is important to try and understand why this happens, and what can be done to reduce its incidence. A literature search using the MEDLINE database was conducted including search terms 'capsular contracture breast augmentation', 'capsular contracture pathogenesis', 'capsular contracture incidence', and 'capsular contracture management', which yielded 82 results which met inclusion criteria. Capsular contracture is caused by an excessive fibrotic reaction to a foreign body (the implant) and has an overall incidence of 10.6%. Risk factors that were identified included the use of smooth (vs. textured) implants, a subglandular (vs. submuscular) placement, use of a silicone (vs. saline) filled implant and previous radiotherapy to the breast. The standard management of capsular contracture is surgical via a capsulectomy or capsulotomy. Medical treatment using the off-label leukotriene receptor antagonist Zafirlukast has been reported to reduce severity and help prevent capsular contracture from forming, as has the use of acellular dermal matrices, botox and neopocket formation. However, nearly all therapeutic approaches are associated with a significant rate of recurrence. Capsular contracture is a multifactorial fibrotic process the precise cause of which is still unknown. The incidence of contracture developing is lower with the use of textured implants, submuscular placement and the use of polyurethane coated implants. Symptomatic capsular contracture is usually managed surgically, however recent research has focussed on preventing capsular contracture from occurring, or treating it with autologous fat transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.