ArticlePakistan journal of medical sciences
Thyroid function status and its impact on clinical outcome in patients admitted to critical care.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Disrupted thyroid hormone homeostasis in critical illness: clinical correlates and associations with hormone supplementation in a single-center retrospective observational study.Anaesthesiology intensive therapy · 2026Observational
- The Association Between Elevated Thyroid-Stimulating Hormone Levels and Prolonged Length of Stay Among Adult Diabetic Patients Hospitalized in Internal Medicine Departments: A Large Historical Cohort Study.Journal of clinical medicine · 2024Article
- Thyroid dysfunction and mortality in cardiovascular hospitalized patients.Cardiovascular endocrinology & metabolism · 2024Article
- Relationship among Low T3 Levels, Type 3 Deiodinase, Oxidative Stress, and Mortality in Sepsis and Septic Shock: Defining Patient Outcomes.International journal of molecular sciences · 2023Article
- Decreased triiodothyronine (T3) as a predictor for prolonged mechanical ventilation in critically ill patients with cardiac surgery.BMC anesthesiology · 2022Article
- Non-thyroidal illness syndrome predicts outcome in adult critically ill patients: a systematic review and meta-analysis.Endocrine connections · 2022Article
- Analysis of the Incidence of Euthyroid Sick Syndrome in Comprehensive Intensive Care Units and Related Risk Factors.Frontiers in endocrinology · 2021Article
- Prognostic Value of Thyroid Hormone FT3 in General Patients Admitted to the Intensive Care Unit.BioMed research international · 2020Observational
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
objectiveTo analyze alterations in thyroid function and the correlation between results of thyroid function test and mortality in medical and surgical intensive care unit (ICU) patients. It also aimed to evaluate the effect of thyroid dysfunction in ICU patients and their need for mechanical ventilation (MV).
methodsA single-center, prospective, observational study was conducted on patients admitted to medical and surgical ICU between 2013-2014.. Clinical and paraclinical findings (free triiodothyronine, free thyroxine and thyroid stimulating hormone) were documented for all patients. Regression analysis and chi-square were used for death and MV outcome variables.
resultsWe included 502 patients. Of these, 340 (67.7%) were admitted to the medical ICU. Results of thyroid function tests were normal in 320 (64%) and 162 (32.3%) medical and surgical ICU patients, respectively. Euthyroid sick syndrome (ESS) was documented in 86 patients (17%). Mortality was twice higher among surgical ICU patients with ESS compared to those with normal thyroid function (p=0.085), which is not statistically significant. Based on thyroid function status, no differences in the risk to be mechanically ventilated was found between medical or surgical ICU patients.
conclusionThere is a significant association between ESS and mortality in ICU patients. Future studies should determine whether abnormal thyroid function increases the risk for MV in ICU patients.
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