Evidence map›Paper›PMID 26430422›Full record

ArticlePakistan journal of medical sciences

Estrogen Receptor Alpha (ESR1) Gene Polymorphisms in Pre-eclamptic Saudi Patients.

Hesham A El-Beshbishy, Manal A Tawfeek, Nevin M Al-Azhary, Reham A Mariah, Fawzia A Habib, Lamya Aljayar, Abrar F Alahmadi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hesham A El-BeshbishyHesham A. El-Beshbishy, Center for Genetics and Inherited Diseases, Taibah University, Madina, Saudi Arabia. Medical Laboratories Technology Department, Faculty of Applied Medical Sciences, Taibah University, Madina, Saudi Arabia. Biochemistry Department, Al-Azhar University, Nasr City, Cairo 11751, Egypt.
Manal A TawfeekManal A. Tawfeek, Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Biochemistry & Molecular Medicine Department, College of Medicine, Taibah University, Madina, Saudi Arabia.
Nevin M Al-AzharyNevin M. Al-Azhary, Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Biochemistry & Molecular Medicine Department, College of Medicine, Taibah University, Madina, Saudi Arabia.
Reham A MariahReham A. Mariah, Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Biochemistry & Molecular Medicine Department, College of Medicine, Taibah University, Madina, Saudi Arabia.
Fawzia A HabibFawzia A. Habib, Obstetrics and Gynecology Department, College of Medicine, Taibah University, Madina, Saudi Arabia.
Lamya AljayarLamya Aljayar, Obstetrics and Gynecology Department, Madina Maternity Children Hospital, Madina, Saudi Arabia.
Abrar F AlahmadiAbrar F. Alahmadi, Obstetrics and Gynecology Department, Madina Maternity Children Hospital, Madina, Saudi Arabia.
Taibah University · SATanta University · EGAl-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPre-eclampsia causes maternal mortality worldwide. Estrogen receptor alpha (ESR1) gene polymorphisms were responsible for cardiovascular diseases. This case control study was conducted to investigate whether 2 polymorphic genes of ESR1 are associated with pre-eclampsia among Saudi women in Madina city, Saudi Arabia.

methodsBlood samples from 97 pre-eclamptic and 94 healthy pregnant women were analyzed using restriction fragment length polymorphism-polymerase chain reaction method. All the subjects were recruited randomly from outpatient clinics of Madina Maternity Children Hospital (MMCH), Madina, Saudi Arabia, between Dec. 2012 and Jan. 2014.

resultsThere was no association between pre-eclampsia and PvuII and XbaI ESR1 gene polymorphisms individually. TT/AA and TT/AG genotype combination existed significantly in pre-eclamptic patients compared to control. The frequency of PvuII and XbaI combined TT/AA genotypes between pre-eclamptic women was 36.1% vs 9.6%, however, frequency of PvuII and XbaI combined TT/AG genotypes between pre-eclamptic women was 3.1% vs 17%, compared to control. The homozygous T-A haplotype carriers showed high pre-eclampsia risk, independent of pregnancy, BMI and smoking status (adjusted odds ratio (OR): 3.26, 95% confidence interval (CI):1.71-9.21). The heterozygous T-A haplotype carriers did not differ from that of non-carriers (adjusted OR: 1.12, 95% CI: 0.47-2.75). No association was observed between pre-eclampsia and T-G, C-G and C-A haplotype of PvuII and XbaIESR1 gene polymorphisms.

conclusionsT-A haplotype of homozygous associated with pre eclampsia not heterozygous carriers of ESR 1 PvuII and XbaI gene polymorphisms elicited high risk of pre-eclampsia. GG genotype of XbaI polymorphism decreased pre-eclampsia risk. Further studies using larger sample size are recommended to investigate the ESR 1 gene polymorphisms associated with pre-eclampsia.

Indexed as

Estrogen receptor alphaPolymorphismPre-eclampsiaPregnancy

Identifiers

PMID26430422
PMCPMC4590376
OpenAlexW2416514484

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.