Evidence map›Paper›PMID 26430389›Full record

ReviewClinical and molecular allergy : CMA2015

Biomarkers and severe asthma: a critical appraisal.

Alessandra Chiappori, Laura De Ferrari, Chiara Folli, Pierluigi Mauri, Anna Maria Riccio, Giorgio Walter Canonica

Abstract readReview
In one paragraph

Review in Clinical and molecular allergy : CMA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Serum Periostin Level in Children with Asthma.Indian journal of pediatrics · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Diagnosis ofBiomedicines · 2022
    Review
  8. Allergic Asthma in the Era of Personalized Medicine.Journal of personalized medicine · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Allergic Endotypes and Phenotypes of Asthma.The journal of allergy and clinical immunology. In practice · 2020
    Article
  15. Article
  16. Plasma Galectin-3 and urine proteomics predict FEVThe World Allergy Organization journal · 2020
    Article
  17. Review
  18. Article
  19. Review
  20. Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessandra Chiappori *DIMI-Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S.Martino-IST, Genoa, Italy.
Laura De Ferrari *DIMI-Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S.Martino-IST, Genoa, Italy.
Chiara FolliDIMI-Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S.Martino-IST, Genoa, Italy.
Pierluigi MauriInstitute for Biomedical Technologies, CNR, Segrate, Milan, Italy.
Anna Maria RiccioDIMI-Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S.Martino-IST, Genoa, Italy.
Giorgio Walter CanonicaDIMI-Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genoa, IRCCS AOU S.Martino-IST, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe asthma (SA) is a clinically and etiologically heterogeneous respiratory disease which affects among 5-10 % of asthmatic patients. Despite high-dose therapy, a large patients percentage is not fully controlled and has a poor quality of life. In this review, we describe the biomarkers actually known in scientific literature and used in clinical practice for SA assessment and management: neutrophils, eosinophils, periostin, fractional exhaled nitric oxide, exhaled breath condensate and galectins. Moreover, we give an overview on clinical and biological features characterizing severe asthma, paying special attention to the potential use of these ones as reliable markers. We finally underline the need to define different biomarkers panels to select patients affected by severe asthma for specific and personalized therapeutic approach.

Indexed as

Allergic inflammationBiomarkersEosinophilExhaled nitric oxideGalectinMonoclonal antibodiesNeutrophilPeriostinSevere asthma

Identifiers

PMID26430389
PMCPMC4590266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.