ArticleEuropean journal of dentistry
Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas.
Article in European journal of dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 51 citations in OpenAlex.
- Investigating GSK-3β as a Potential Prognostic Marker for Metastasis in Head and Neck Squamous Cell Carcinoma: A Preliminary Study on the Crossroads of GABAergic and Wnt Signaling.European journal of dentistry · 2026Article
- Article
- Etiopathogenesis of Oral Lichen Planus: A Review.Head and neck pathology · 2025Review
- A Decadal Bibliometric Analysis on the Therapeutic Strategies in Oral Lichen Planus.Health science reports · 2025Article
- Comparative study of E-cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions.Dental research journal · 2025Article
- Comparison of E-Cadherin Expression in Oral Verrucous Carcinoma and Normal Oral Mucosa: An Immunohistochemical Study.Cureus · 2024Article
- Immediate but Temporal Response: The Role of Distal Epithelial Cells in Wound Healing.Stem cell reviews and reports · 2024Article
- Review
- Estimation of depression, anxiety and serum cortisol in patients with oral lichen planus, leukoplakia and oral submucous fibrosis.Bioinformation · 2024Article
- Oral squamous carcinoma cell lysates provoke exacerbated inflammatory response in gingival fibroblasts.Clinical oral investigations · 2023Article
- Effect of CDH1 and CDH2 genes polymorphisms in oral squamous cell carcinoma susceptibility in a sample of Iranian population: A case-control study.Health science reports · 2023Article
- Altered expression of junctional proteins as a potential biomarker in oral precancerous and cancerous patients.Tissue barriers · 2022Article
- Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis.Mucosal immunology · 2021Review
- Analysis of DNA methylation of E-cadherin and p16Clinical and experimental dental research · 2021Article
- Expression of E- Cadherin and Levels of Dysplasia in Oral Leukoplakia - A Prospective Cohort Study.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Prediction of metastasis in oral squamous cell carcinoma through phenotypic evaluation and gene expression of E-cadherin, β-catenin, matrix metalloproteinase-2, and matrix metalloproteinase-9 biomarkers with clinical correlation.Journal of carcinogenesis · 2020Article
- Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review.European journal of dentistry · 2019Article
- Histomorphometric Comparative Analysis between Oral Dysplastic Potentially Malignant Disorders and Oral Squamous Cell Carcinoma.European journal of dentistry · 2019Article
- Markers of Oral Lichen Planus Malignant Transformation.Disease markers · 2018Review
- Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva.Medicina oral, patologia oral y cirugia bucal · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present study was to assess the expression of E-cad in oral precancerous lesions and conditions and oral carcinomas in comparison with normal mucosa. MATERIALS AND
methodsTotal of 50 samples were selected for the study and were categorized into five groups and 10 samples in each group as Group I-oral leukoplakia (OL), Group II-oral lichen planus (OLP), Group III-oral submucous fibrosis (OSMF), Group IV-oral squamous cell carcinoma (OSCC) and Group V-normal oral mucosa (NOM) as control group. All the samples were assessed for the expression of E-cad by immunohistochemical study.
resultsUpon assessing the expression of E-cad in OL, OSMF, OLP and OSCC, as majority of the samples with OSCC (90%), OL (80%), OLP (70%) and OSMF (60%) showed mild to moderate expression of E-cad staining, which was suggestive of reduction in dysplastic cells on comparison to NOM cells. This difference in expression and variation of E-cad upon comparison with normal mucosa was statistically significant (P < 0.001).
conclusionThere is significant (P < 0.001) variation of expression of E-cad with the histopathological dysplasia of the oral precancerous lesions and conditions, and the tumor differentiation of the oral cancers. However, there was no correlation of the degree of loss of expression of E-cad with the degree of dysplasia or the tumor differentiation of oral cancers. We conclude with our study that, there is a variation in the expression of E-cad but its value as a prognostic marker is questionable.
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