ArticleEuropean journal of dentistry
The influence of type 2 diabetes mellitus on salivary matrix metalloproteinase-8 levels and periodontal parameters: A study in an Indian population.
Article in European journal of dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- From biological evidence to clinical application: a scoping review of oral fluid biomarkers in type 2 diabetic periodontitis.Frontiers in oral health · 2026Review
- Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues.European journal of dentistry · 2025Article
- The effect of different bioceramic root canal sealer removal protocols on the bond strength of composite to coronal dentin in diabetic and non-diabetic patients: an ex vivo study.BMC oral health · 2025Article
- Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis.Oral diseases · 2025Article
- Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements.Journal of functional biomaterials · 2024Article
- Comparing the activity level of salivary matrix metalloproteinase-8 in patients with diabetes and moderate to severe chronic generalized periodontitis.Clinical and experimental dental research · 2024Article
- Alveolar Bone Loss in Diabetic Patients: A Case-Control Study.European journal of dentistry · 2024Article
- IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study.European journal of dentistry · 2023Article
- Comparative Study of Cytokeratin Immunostaining of Parotid Gland Parenchyma in Normal, Diabetic, and Excretory Duct Ligation of Mongrel Dogs.European journal of dentistry · 2023Article
- The effect of diabetes on the tensile bond strength of a restorative dental composite to dentin.Odontology · 2022Article
- Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients.European journal of dentistry · 2021Article
- Biomarker for Asymptomatic Apical Periodontitis in Gingival Crevicular Fluid: aMMP-8.European journal of dentistry · 2020Article
- Relationship between General Health Behaviors and Oral Health Behaviors in 2015-2016 NHANES Adult Population.European journal of dentistry · 2019Article
- Preventive dental care in older adults with diabetes.Journal of the American Dental Association (1939) · 2016Article
- Modulating toll-like receptor-mediated inflammatory responses following exposure of whole cell and lipopolysaccharide component fromEuropean journal of dentistryArticle
- Periodontal health status and implication of periodic acid-Schiff diastase - a key in exfoliative cytology among diabetics mellitus patients: A case-control study.European journal of dentistryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough many studies reported more severe periodontal disease and the existing proinflammatory conditions in patients with diabetes but only few have examined the effect of type 2 diabetes mellitus (DM) on salivary matrix metalloproteinase-8 (MMP-8) level and other periodontal parameters. This study aims to evaluate the effect of type 2 DM on salivary MMP-8 levels and periodontal parameters, which might be useful in monitoring periodontal disease in diabetes. MATERIALS AND
methodsA total of 90 subjects were selected for the study and were divided into three groups: Group I included 30 healthy subjects; Group II included 30 subjects without type 2 DM but with chronic periodontitis, and Group III included 30 subjects with type 2 DM and chronic periodontitis. Periodontal parameters such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), and clinical attachment level (CAL) were taken. The salivary MMP-8 level was estimated by Quantikine Human total MMP-8 immunoassay kit using ELISA method.
resultsThe mean value of the salivary MMP-8 of Group III was highest followed by Group II and Group I, the least. The other periodontal parameters PI, GI, PPD, CAL, was comparatively highest for Group III.
conclusionThis study suggests that diabetes is associated with an increased prevalence, extent, and severity of periodontitis. Furthermore, the increased levels of MMP-8 indicate the influence of diabetes on their salivary concentration.
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