Evidence map›Paper›PMID 26430170›Full record

GuidelinePediatrics2015

Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research.

Lonnie Zwaigenbaum, Margaret L Bauman, Roula Choueiri, Connie Kasari, Alice Carter, Doreen Granpeesheh, Zoe Mailloux, Susanne Smith Roley, Sheldon Wagner, Deborah Fein and 12 more

Abstract readConsensus StatementPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Quality of Life in Autism: A Systematic Review and Meta-Analysis of Patients and Caregivers.Autism research : official journal of the International Society for Autism Research · 2026
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  5. Who, when, where, and why: A systematic review of "late diagnosis" in autism.Autism research : official journal of the International Society for Autism Research · 2025
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245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lonnie ZwaigenbaumDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; lonniez@ualberta.ca.
Margaret L BaumanDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts;
Roula ChoueiriDivision of Developmental and Behavioral Pediatrics, University of Massachusetts Memorial Children's Medical Center, Worcester, Massachusetts;
Connie KasariGraduate School of Education & Information Studies, University of California Los Angeles, Los Angeles, California;
Alice CarterDepartment of Psychology, University of Massachusetts, Boston, Massachusetts;
Doreen GranpeeshehCenter for Autism and Related Disorders, Tarzana, California;
Zoe MaillouxDepartment of Occupational Therapy, Thomas Jefferson University, Philadelphia, Pennsylvania;
Susanne Smith RoleyUSC Mrs T.H. Chan Division of Occupational Science and Occupational Therapy, Los Angeles, California;
Sheldon WagnerBehavioral Development & Educational Services, New Bedford, Massachusetts;
Deborah FeinDepartment of Psychology, University of Connecticut, Storrs, Connecticut;
Karen PierceDepartment of Neurosciences, University of California San Diego, La Jolla, California;
Timothy BuieHarvard Medical School and Massachusetts General Hospital for Children, Boston, Massachusetts;
Patricia A DavisIntegrated Center for Child Development, Newton, Massachusetts;
Craig NewschafferA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania;
Diana RobinsA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania;
Amy WetherbyDepartment of Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida;
Wendy L StoneDepartments of Psychology, and.
Nurit YirmiyaDepartment of Psychology, Hebrew University of Jerusalem Mount Scopus, Jerusalem, Israel;
Annette EstesSpeech and Hearing Sciences, University of Washington, Seattle, Washington;
Robin L HansenDepartment of Pediatrics, University of California Davis MIND Institute, Sacramento, California;
James C McPartlandYale Child Study Center, New Haven, Connecticut; and.
Marvin R NatowiczGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Funding

Detection of ASD at the 1st birthday as standard of care: The Get SET Early ModelR01MH104446 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2014 to 2018
$6.0M
Studying the Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up AppR01MH080134 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2008 to 2017
$3.3M
NIMH NIH HHS R01 MH080134NIMH NIH HHS R01 MH104446
6 · The paper itself

Abstract

This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged <3 years, based on peer-reviewed articles published up to December 2013. Several groups have adapted treatments initially designed for older, preschool-aged children with ASD, integrating best practice in behavioral teaching methods into a developmental framework based on current scientific understanding of how infants and toddlers learn. The central role of parents has been emphasized, and interventions are designed to incorporate learning opportunities into everyday activities, capitalize on "teachable moments," and facilitate the generalization of skills beyond the familiar home setting. Our review identified several comprehensive and targeted treatment models with evidence of clear benefits. Although some trials were limited to 8- to 12-week outcome data, enhanced outcomes associated with some interventions were evaluated over periods as long as 2 years. Based on this review, recommendations are proposed for clinical practice and future research.

Indexed as

Autism Spectrum DisorderBiomedical ResearchChild, PreschoolEarly Medical InterventionHumansInfantParents

Identifiers

PMID26430170
PMCPMC9923898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.