Evidence map›Paper›PMID 26429963›Full record

ArticleBlood2015

MAGiC: VOC remains but kids with SCA appear.

Jeremie Heath Estepp

Registry-linked trialOpen access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Blood, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01197417 (Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01197417 phase2 / phase3completednot on this map

Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis

TypeinterventionalSponsorMedical College of WisconsinRan2010 to 2014Enrolled208ConditionsSickle Cell DiseaseArmsIntravenous Magnesium Sulfate, Normal Saline Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Magnesium for treating sickle cell disease.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Magnesium for treating sickle cell disease.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeremie Heath EsteppST. JUDE CHILDREN RESEARCH HOSPITAL.
St. Jude Children's Research Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Blood, Brousseau et al report results from the Magnesium for Children in Crisis (MAGiC; #NCT01197417) trial. This multicenter, double-blind, placebo-controlled trial compared the effects of intravenous magnesium to saline in children with sickle cell anemia (SCA) admitted to the hospital for acute vaso-occlusive pain (VOC). Although magnesium was found to be ineffective, MAGiC illustrates an effective strategy for rapid and efficient patient accrual in pediatric SCA studies.

Indexed as

Anemia, Sickle CellFemaleHumansMagnesiumMalePainVasodilator AgentsMagnesiumVasodilator Agents

Identifiers

PMID26429963
OpenAlexW2416085373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.