Evidence map›Paper›PMID 26429935›Full record

ArticleCancer discovery2015

"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.

Stephen C Mack, Jeremy N Rich, Peter C Scacheri

Open access · greenAbstract readComment
In one paragraph

Article in Cancer discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. A novel epigeneticEMBO molecular medicine · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Stephen C MackDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Jeremy N RichDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio. pxs183@case.edu.
Cleveland Clinic Lerner College of Medicine · USCase Western Reserve University · US

Funding

The role of gene enhancer elements in colon cancerR01CA160356 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TESAR, PAUL JOSEPH · 2012 to 2023
$3.6M
Targeting Ferritin in GlioblastomaR01CA169117 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI BAO, SHIDENG, CONNOR, JAMES ROBERT · 2013 to 2017
$2.7M
Metabolism Informs Intertumoral & Intratumoral HeterogeneityR01NS087913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NAKANO, ICHIRO, RICH, JEREMY N · 2014 to 2018
$2.0M
Targeting Brain Tumor Stem Cells Through Novel Therapeutic CombinationsR01CA154130 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI RICH, JEREMY N · 2010 to 2014
$1.9M
Energy Stress in Brain Tumor Initiating Stem CellsR01NS089272 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICH, JEREMY N · 2014 to 2018
$1.7M
Instructive Cues in Glioblastoma HierarchiesR01CA171652 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI RICH, JEREMY N · 2014 to 2014
$421k
NCI NIH HHS CA154130NCI NIH HHS R01 CA154130NCI NIH HHS R01 CA160356NCI NIH HHS R01CA160356NCI NIH HHS R01 CA169117NCI NIH HHS R01 CA171652NINDS NIH HHS R01 NS087913NINDS NIH HHS R01 NS089272
6 · The paper itself

Abstract

Somatic structural variants in tumor genomes can deregulate transcription through repositioning of enhancer elements. A new method, PEAR-ChIP, leverages paired-end H3K27ac chromatin immunoprecipitation combined with high-throughput sequencing and current computational methods to identify such events.

Indexed as

Enhancer Elements, GeneticGene Expression Regulation, NeoplasticGene RearrangementOncogenesHumansLymphoma, B-Cell

Identifiers

PMID26429935
PMCPMC4608252
OpenAlexW2173041025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.