Evidence map›Paper›PMID 26429788›Full record

Trial reportAnnals of biomedical engineering2016

Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images.

Byron A Zambrano, Hamidreza Gharahi, ChaeYoung Lim, Farhad A Jaberi, Jongeun Choi, Whal Lee, Seungik Baek

Abstract readClinical Trial
In one paragraph

Trial report in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 116 citations in OpenAlex.

  1. Article
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  11. Hemodynamics in Cerebral Aneurysms and Parent Arteries With Incompletely Expanded Flow Diverter Stents.International journal for numerical methods in biomedical engineering · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Byron A ZambranoDepartment of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
Hamidreza GharahiDepartment of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
ChaeYoung LimDepartment of Statistics and Probability, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
Farhad A JaberiDepartment of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
Jongeun ChoiDepartment of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
Whal LeeDepartment of Radiology, 101 Daehangno, Jongno-gu, Seoul, Korea.
Seungik BaekDepartment of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA. sbaek@egr.msu.edu.
Michigan State University · USDaehang Hospital · KR

Funding

Growth and Remodeling Model of Abdominal Aortic Aneurysm: Toward Clinical ApplicaR01HL115185 · NHLBI · MICHIGAN STATE UNIVERSITY · PI BAEK, SEUNGIK · 2012 to 2015
$753k
Quantitative Analysis of Relationships Among Hemodynamics, Thrombus, and AbdominaR21HL113857 · NHLBI · MICHIGAN STATE UNIVERSITY · PI BAEK, SEUNGIK · 2013 to 2014
$384k
NHLBI NIH HHS R01 HL115185NHLBI NIH HHS R01HL115185NHLBI NIH HHS R21 HL113857
6 · The paper itself

Abstract

While hemodynamic forces and intraluminal thrombus (ILT) are believed to play important roles on abdominal aortic aneurysm (AAA), it has been suggested that hemodynamic forces and ILT also interact with each other, making it a complex problem. There is, however, a pressing need to understand relationships among three factors: hemodynamics, ILT accumulation, and AAA expansion for AAA prognosis. Hence this study used longitudinal computer tomography scans from 14 patients and analyzed the relationship between them. Hemodynamic forces, represented by wall shear stress (WSS), were obtained from computational fluid dynamics; ILT accumulation was described by ILT thickness distribution changes between consecutives scans, and ILT accumulation and AAA expansion rates were estimated from changes in ILT and AAA volume. Results showed that, while low WSS was observed at regions where ILT accumulated, the rate at which ILT accumulated occurred at the same rate as the aneurysm expansion. Comparison between AAAs with and without thrombus showed that aneurysm with ILT recorded lower values of WSS and higher values of AAA expansion than those without thrombus. Findings suggest that low WSS may promote ILT accumulation and submit the idea that by increasing WSS levels ILT accumulation may be prevented.

Indexed as

Aortic Aneurysm, AbdominalHemodynamicsModels, CardiovascularThrombosisTomography, X-Ray ComputedAortographyFemaleFollow-Up StudiesHumansMaleCFDThrombosisVascular growth and remodeling

Identifiers

PMID26429788
PMCPMC4826625
OpenAlexW2179397665

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.