Trial reportDeutsches Arzteblatt international2015
Lung Cancer Screening Using Low Dose CT Scanning in Germany. Extrapolation of results from the National Lung Screening Trial.
Trial report in Deutsches Arzteblatt international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Lung Cancer Screening With Low-Dose Computed Tomography.Deutsches Arzteblatt international · 2023Pooled it
- Recommendations from the European Society of Thoracic Surgeons (ESTS) regarding computed tomography screening for lung cancer in Europe.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2017Guideline
- Necessity of organized low-dose computed tomography screening for lung cancer: From epidemiologic comparisons between China and the Western nations.Oncotarget · 2017Pooled it
- Article
- Prognostic Impact of the Angiogenic GeneFrontiers in oncology · 2022Article
- Article
- Lung Cancer Screening with Low-Dose CT in Smokers: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2021Review
- Evidence-Based Follow-up for Adults With Cancer.Deutsches Arzteblatt international · 2019Review
- Challenges in Lung Cancer Screening in Latin America.Journal of global oncology · 2018Review
- High-resolution computed tomography features and CT-guided microcoil localization of subcentimeter pulmonary ground-glass opacities: radiological processing prior to video-assisted thoracoscopic surgery.Journal of thoracic disease · 2018Article
- In Reply.Deutsches Arzteblatt international · 2016Article
- Substantiated Modelling Instead of Flying Blind.Deutsches Arzteblatt international · 2016Article
- Implementation and organization of lung cancer screening.Annals of translational medicine · 2016Review
- Article
- Screening for Lung Cancer: Balancing Hope With Doubt About Applicability.Deutsches Arzteblatt international · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is now debated whether the screening of heavy smokers for lung cancer with low dose computed tomography (low dose CT) might lower their mortality due to lung cancer. We use data from the National Lung Screening Trial (NLST) in the USA to predict the likely effects of such screening in Germany.
methodsThe number of heavy smokers aged 55-74 in Germany was extrapolated from survey data obtained by the Robert Koch Institute. Published data from the NLST were then used to estimate the likely effects of low dose CT screening of heavy smokers in Germany.
resultsIf low dose CT screening were performed on 50% of the heavy smokers in Germany aged 55-74, an estimated 1 329 506 persons would undergo such screening. If the screening were repeated annually, then, over three years, 916 918 screening CTs would reveal suspect lesions, and the diagnosis of lung cancer would be confirmed thereafter in 32 826 persons. At least one positive test result in three years would be obtained in 39.1% of the participants (519 837 persons). 4155 deaths from lung cancer would be prevented over 6.5 years, and the number of persons aged 55-74 who die of lung cancer in Germany would fall by 2.6%. 12 449 persons would have at least one complication, and 1074 persons would die in the 60 days following screening.
conclusionThe screening of heavy smokers for lung cancer can lower their risk of dying of lung cancer by 20% in relative terms, corresponding to an absolute risk reduction of 0.3 percentage points. These figures can provide the background for a critical discussion of the putative utility of this type of screening in Germany.
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