ArticleAnnals of intensive care2015
Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. A groupe de recherche respiratoire en réanimation onco-hématologique (Grrr-OH) study.
Article in Annals of intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Outcomes in Critically Ill Haematological Patients. The Use of Intensive Care in Critically Ill Cancer Haematological Patients
Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Critically ill allogenic HSCT patients in the intensive care unit: a systematic review and meta-analysis of prognostic factors of mortality.Bone marrow transplantation · 2018Pooled it
- Prognostic Factors and Clinical Outcomes in Critically Ill Patients with Hematological Malignancies in the Intensive Care Unit.Journal of clinical medicine · 2026Article
- Review
- Management of analgosedation during noninvasive respiratory support: an expert Delphi consensus document developed by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI).Journal of anesthesia, analgesia and critical care · 2024Article
- High-value care for critically ill oncohematological patients: what do we know thus far?Critical care science · 2023Review
- Article
- A combination of the APACHE II score, neutrophil/lymphocyte ratio, and expired tidal volume could predict non-invasive ventilation failure in pneumonia-induced mild to moderate acute respiratory distress syndrome patients.Annals of translational medicine · 2022Article
- Oxygenation strategy during acute respiratory failure in immunocompromised patients.Journal of intensive medicine · 2021Review
- Management strategy for hematological malignancy patients with acute respiratory failure.European journal of medical research · 2021Review
- Review
- Observational
- Acute respiratory failure in immunocompromised adults.The Lancet. Respiratory medicine · 2019Review
- Predictors of high flow nasal cannula failure in immunocompromised patients with acute respiratory failure due to non-HIV pneumocystis pneumonia.Journal of thoracic disease · 2017Article
- Characteristics and Outcomes of Patients with Hematological Malignancies Admitted for Intensive Care - a Single Centre ExperienceAsian Pacific journal of cancer prevention : APJCP · 2017Article
- High-flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure.Annals of translational medicine · 2017Review
- Critically ill allogeneic hematopoietic stem cell transplantation patients in the intensive care unit: reappraisal of actual prognosis.Bone marrow transplantation · 2016Review
- Critically ill patients with cancer: chances and limitations of intensive care medicine-a narrative review.ESMO open · 2016Review
- New puzzles for the use of non-invasive ventilation for immunosuppressed patients.Journal of thoracic disease · 2016Article
- Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation.Annals of thoracic medicineArticle
- Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with hematological malignancies and acute respiratory failure (ARF), noninvasive ventilation was associated with a decreased mortality in older studies. However, mortality of intubated patients decreased in the last years. In this study, we assess outcomes in those patients according to the initial ventilation strategy.
methodsWe performed a post hoc analysis of a prospective multicentre study of critically ill hematology patients, in 17 intensive care units in France and Belgium. Patients with hematological malignancies admitted for ARF in 2010 and 2011 and who were not intubated at admission were included in the study. A propensity score-based approach was used to assess the impact of NIV compared to oxygen only on hospital mortality.
resultsAmong 1011 patients admitted to ICU during the study period, 380 met inclusion criteria. Underlying diseases included lymphoid (n = 162, 42.6 %) or myeloid (n = 141, 37.1 %) diseases. ARF etiologies were pulmonary infections (n = 161, 43 %), malignant infiltration (n = 65, 17 %) or cardiac pulmonary edema (n = 40, 10 %). Mechanical ventilation was ultimately needed in 94 (24.7 %) patients, within 3 [2-5] days of ICU admission. Hospital mortality was 32 % (123 deaths). At ICU admission, 142 patients received first-line noninvasive ventilation (NIV), whereas 238 received oxygen only. Fifty-five patients in each group (NIV or oxygen only) were matched according the propensity score. NIV was not associated with decreased hospital mortality [OR 1.5 (0.62-3.65)].
conclusionsIn hematology patients with acute respiratory failure, initial treatment with NIV did not improve survival compared to oxygen only. CLINICAL TRIAL: gov number NCT 01172132.
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Registered trials
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