ArticleThe Journal of clinical investigation1989
Protective immunity in bancroftian filariasis. Selective recognition of a 43-kD larval stage antigen by infection-free individuals in an endemic area.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 96 citations in OpenAlex.
- Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle WithFrontiers in cellular and infection microbiology · 2022Review
- Examining the role of macrolides and host immunity in combatting filarial parasites.Parasites & vectors · 2017Review
- Cofactor independent phosphoglycerate mutase of Brugia malayi induces a mixed Th1/Th2 type immune response and inhibits larval development in the host.BioMed research international · 2014Article
- Insights into the pathogenesis of disease in human lymphatic filariasis.Lymphatic research and biology · 2013Review
- Large extracellular loop of tetraspanin as a potential vaccine candidate for filariasis.PloS one · 2013Article
- IgG subclass responses to proinflammatory fraction of Brugia malayi in human filariasis.The Indian journal of medical research · 2012Article
- Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis.PLoS neglected tropical diseases · 2009Article
- Brugia malayi adult low molecular weight IgG4-reactive antigens induce differential cytokine response in lymphocytes of endemic normal and asymptomatic microfilariae carriers in vitro.Journal of clinical immunology · 2007Article
- Novel phage display-based subtractive screening to identify vaccine candidates of Brugia malayi.Infection and immunity · 2004Article
- Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity.Infection and immunity · 2003Article
- Host protective immunity and vaccine development studies in lymphatic filariasis.Indian journal of clinical biochemistry : IJCB · 2000Article
- The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis.Infection and immunity · 2000Article
- The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection.Immunology · 1997Article
- The novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively immune individuals.Infection and immunity · 1997Article
- Th1-like antifilarial immune responses predominate in antigen-negative persons.Infection and immunity · 1996Article
- Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti.Infection and immunity · 1994Article
- Ivermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection.Clinical and experimental immunology · 1994Article
- Molecular parasitology: progress towards the development of vaccines for malaria, filariasis, and schistosomiasis.Experientia · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is little information about naturally occurring protective immunity in individuals living in areas endemic for lymphatic filariasis, though an immunologically hyperresponsive, uninfected group of "endemic normal" individuals that may be immune has been previously recognized. To analyze the nature of the hyperresponsiveness and its potential relation to a state of protective immunity in such individuals, strict clinical, parasitological, and serological criteria were applied to select seven "infection-free" endemic normal individuals (ENs) from a population of 459 persons resident in an area heavily endemic for bancroftian filariasis. Immunoblot analysis was used to compare the qualitative antigen recognition patterns of these endemic normal individuals to those of a group of 12 clearly infected microfilaremic individuals (MFs) from the same endemic area. Though immunoblot analysis using microfilarial and adult stage filarial antigens revealed no distinct differences in antigen recognition patterns between the two groups, when responses to infective larval stage antigens were assessed, 7/7 (100%) of the ENs were found to recognize a 43-kD antigen that was recognized by only 1/12 (8%) of the MFs. These findings are consistent with the concept that recognition of unique larval antigens may induce protective immunity to human filarial parasites and they identify a candidate immunogen for further functional assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.